Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum
Ordering Recommendation
Useful for the evaluation of classic paraneoplastic neurologic syndrome.
Methodology
Qualitative Immunoblot
Performed
Mon, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum separator tube
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.30 mL)
Refrigerated
Plasma. Contaminated, heat-inactivated, grossly hemolyzed, or lipemic specimens
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Neuronal Nuclear Ab (Yo) IgG, IB, Serum | Negative | |
Neuronal Nuclear Ab (TR/DNER) IgG, IB | Negative | |
Neuronal Nuclear Ab (Ri) IgG, IB, Serum | Negative | |
Neuronal Nuclear Ab (Hu) IgG, IB, Serum | Negative |
Interpretive Data
This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.
Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and with fallopian tube and breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr(DNER) is associated with Hodgkin's lymphoma.
The presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
84182 x4
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3002918 | Neuronal Nuclear Ab (Yo) IgG, IB, Serum | 12853-8 |
3002919 | Neuronal Nuclear Ab (TR/DNER) IgG, IB | 63440-2 |
3002920 | Neuronal Nuclear Ab (Ri) IgG, IB, Serum | 33008-4 |
3002921 | Neuronal Nuclear Ab (Hu) IgG, IB, Serum | 41769-1 |
Aliases
- DNER
- Hu, Ri, Yo, and Tr/DNER Ab
- Hu; Ri; Yo; Tr/DNER
- Neuronal Ab Immunoblot
- Neuronal Nuclear Ab IgG
- Paraneoplastic
- PCA-3
- Tr