Useful for the evaluation of classic paraneoplastic neurologic syndrome.
Mon, Thu, Sat
Serum separator tube
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.30 mL)
Plasma. Contaminated, heat-inactivated, grossly hemolyzed, or lipemic specimens
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
|Neuronal Nuclear Ab (Yo) IgG, IB, Serum||Negative|
|Neuronal Nuclear Ab (TR/DNER) IgG, IB||Negative|
|Neuronal Nuclear Ab (Ri) IgG, IB, Serum||Negative|
|Neuronal Nuclear Ab (Hu) IgG, IB, Serum||Negative|
This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.
Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and with fallopian tube and breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr(DNER) is associated with Hodgkin's lymphoma.
The presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|3002918||Neuronal Nuclear Ab (Yo) IgG, IB, Serum||12853-8|
|3002919||Neuronal Nuclear Ab (TR/DNER) IgG, IB||63440-2|
|3002920||Neuronal Nuclear Ab (Ri) IgG, IB, Serum||33008-4|
|3002921||Neuronal Nuclear Ab (Hu) IgG, IB, Serum||41769-1|
- Hu, Ri, Yo, and Tr/DNER Ab
- Hu; Ri; Yo; Tr/DNER
- Neuronal Ab Immunoblot
- Neuronal Nuclear Ab IgG