Ordering Recommendation

Useful for the evaluation of classic paraneoplastic neurologic syndrome.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.30 mL)

Storage/Transport Temperature


Unacceptable Conditions

Plasma. Contaminated, heat-inactivated, grossly hemolyzed, or lipemic specimens


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Qualitative Immunoblot


Mon, Thu, Sat


1-4 days

Reference Interval

Test Number
Reference Interval
  Neuronal Nuclear Ab (Yo) IgG, IB, Serum Negative
  Neuronal Nuclear Ab (TR/DNER) IgG, IB Negative
  Neuronal Nuclear Ab (Ri) IgG, IB, Serum Negative
  Neuronal Nuclear Ab (Hu) IgG, IB, Serum Negative

Interpretive Data

This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.

Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and with fallopian tube and breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr(DNER) is associated with Hodgkin's lymphoma.

The presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

84182 x4


Component Test Code* Component Chart Name LOINC
3002918 Neuronal Nuclear Ab (Yo) IgG, IB, Serum 12853-8
3002919 Neuronal Nuclear Ab (TR/DNER) IgG, IB 63440-2
3002920 Neuronal Nuclear Ab (Ri) IgG, IB, Serum 33008-4
3002921 Neuronal Nuclear Ab (Hu) IgG, IB, Serum 41769-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • DNER
  • Hu, Ri, Yo, and Tr/DNER Ab
  • Hu; Ri; Yo; Tr/DNER
  • Neuronal Ab Immunoblot
  • Neuronal Nuclear Ab IgG
  • Paraneoplastic
  • PCA-3
  • Tr
Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum