Ordering Recommendation

Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy. Serum is the preferred specimen; refer to Autoimmune Neurologic Disease Reflexive Panel, Serum (3003058).

Mnemonic
NEURORCSF
Methodology

Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semi-quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF

Specimen Preparation

Transfer three 1 mL CSF aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Fluid other than CSF. Grossly hemolyzed specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
2005164 N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer Effective May 21, 2012
< 1:1
3001257 Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF Less than 1:1
3001267 Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF Less than 1:1
3001986 Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, CSF Less than 1:1
3001387 Voltage-Gated Potassium Channel (VGKC) Antibody, CSF
Negative 0.0-1.1 pmol/L
Positive 1.2 pmol/L or greater

2010841 Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF
Test Number
Components
Reference Interval
  Paraneoplastic Abs (PCCA/ANNA) IgG, CSF Refer to report
  Neuronal Nuclear Ab Titer, IgG CSF Refer to report
  Purkinje Cell Antibody Titer IgG, CSF Refer to report
2010847 Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by Immunoblot, CSF Refer to report

3001992 Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, CSF Less than 1:1
3002257 CV2.1 Screen by IFA with Reflex to Titer, CSF Less than 1:1
3002788 Glutamic Acid Decarboxylase Antibody, CSF 0.0-5.0 IU/mL
3002886 SOX1 Antibody, IgG by Immunoblot, CSF Negative

Interpretive Data

Refer to Report

Compliance Category

Laboratory Developed Test (LDT)

Note

If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.
If Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF IgG is positive, then an Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody Titer, IgG, CSF is reported. Additional charges apply.
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, CSF is performed. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
PCCA/ANNA antibodies are screened by IFA. If the IFA screen is indeterminate then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA, CSF is positive, then CV2.1 Antibody IgG Titer, CSF will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

86255; if reflexed, add 86256
86255; if reflexed, add 86256
86255; if reflexed, add 86256
86255; if reflexed, add 86256
83519
86255; if reflexed add 84182 x3 and/or 86256
86255; if reflexed, add 86256
86255; if reflexed, add 86256
86341
84182

Components
Component Test Code* Component Chart Name LOINC
2005165 N-methyl-D-Aspartate Receptor Ab, CSF 80220-7
2010842 Paraneoplastic Abs (PCCA/ANNA) IgG, CSF
3001258 AMPA Receptor Ab IgG Screen, CSF 82732-9
3001268 GABA-B Receptor Ab IgG Screen, CSF 82984-6
3001388 Voltage-Gated Potassium Channel Ab, CSF 68913-3
3001987 CASPR2 Ab IgG Screen by IFA, CSF 90820-2
3001991 LGI1 Ab IgG Screen by IFA, CSF 90830-1
3002259 CV2.1 Ab IgG Screen, CSF 53707-6
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
3002904 SOX1 Antibody, IgG by Immunoblot, CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Autoimmune Neurologic Disease Reflexive Panel, CSF