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Autoimmune Neurologic Disease Reflexive Panel, CSF
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Ordering Recommendation
Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy. Serum is the preferred specimen; refer to Autoimmune Neurologic Disease Reflexive Panel, Serum (3003058).
Mnemonic
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semi-quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
CSF
Transfer three 1 mL CSF aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Frozen
Fluid other than CSF. Grossly hemolyzed specimens.
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005164 | N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer | Effective May 21, 2012 < 1:1 |
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| 3001257 | Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF | Less than 1:1 | |||||||||||||||
| 3001267 | Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF | Less than 1:1 | |||||||||||||||
| 3001986 | Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, CSF | Less than 1:1 | |||||||||||||||
| 3001387 | Voltage-Gated Potassium Channel (VGKC) Antibody, CSF |
|
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| 2010841 | Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF |
|
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| 3001992 | Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, CSF | Less than 1:1 | |||||||||||||||
| 3002257 | CV2.1 Screen by IFA with Reflex to Titer, CSF | Less than 1:1 | |||||||||||||||
| 3002788 | Glutamic Acid Decarboxylase Antibody, CSF | 0.0-5.0 IU/mL | |||||||||||||||
| 3002886 | SOX1 Antibody, IgG by Immunoblot, CSF | Negative |
Interpretive Data
Refer to Report
Laboratory Developed Test (LDT)
Note
If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.
If Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF IgG is positive, then an Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody Titer, IgG, CSF is reported. Additional charges apply.
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, CSF is performed. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
PCCA/ANNA antibodies are screened by IFA. If the IFA screen is indeterminate then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA, CSF is positive, then CV2.1 Antibody IgG Titer, CSF will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86255 x7; 83519; 86341; 84182; if reflexed, add 84182 x3; 86256 x8
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005165 | N-methyl-D-Aspartate Receptor Ab, CSF | 80220-7 |
| 2010842 | Paraneoplastic Abs (PCCA/ANNA) IgG, CSF | 14247-1 |
| 3001258 | AMPA Receptor Ab IgG Screen, CSF | 82732-9 |
| 3001268 | GABA-B Receptor Ab IgG Screen, CSF | 82984-6 |
| 3001388 | Voltage-Gated Potassium Channel Ab, CSF | 68913-3 |
| 3001987 | CASPR2 Ab IgG Screen by IFA, CSF | 90820-2 |
| 3001991 | LGI1 Ab IgG Screen by IFA, CSF | 90830-1 |
| 3002259 | CV2.1 Ab IgG Screen, CSF | 53707-6 |
| 3002789 | Glutamic Acid Decarboxylase Antibody CSF | 42501-7 |
| 3002904 | SOX1 Antibody, IgG by Immunoblot, CSF |
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