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Autoimmune Neurologic Disease Reflexive Panel, CSF
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Ordering Recommendation
Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy. Serum is the preferred specimen; refer to Autoimmune Neurologic Disease Reflexive Panel, Serum (3004070).
Mnemonic
Methodology
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semi-quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
CSF
Transfer three 1 mL CSF aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Frozen
Fluid other than CSF. Grossly hemolyzed specimens.
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| N-methyl-D-Aspartate Receptor Ab, CSF | Less than 1:1 | |
| Paraneoplastic Abs (PCCA/ANNA) IgG, CSF | None Detected | |
| AMPA Receptor Ab IgG Screen, CSF | Less than 1:1 | |
| GABA-B Receptor Ab IgG Screen, CSF | Less than 1:1 | |
| Voltage-Gated Potassium Channel Ab, CSF | 0.0-1.1 pmol/L | |
| CASPR2 Ab IgG Screen by IFA, CSF | Less than 1:1 | |
| LGI1 Ab IgG Screen by IFA, CSF | Less than 1:1 | |
| CV2.1 Ab IgG Screen, CSF | Less than 1:1 | |
| Glutamic Acid Decarboxylase Antibody CSF | 0.0-5.0 IU/mL | |
| SOX1 Antibody, IgG by Immunoblot, CSF | Negative | |
| Amphiphysin Antibody, CSF | Negative | |
| DPPX Ab IgG CBA IFA Screen, CSF | Less than 1:1 |
Interpretive Data
Refer to Report
| Component |
Interpretive Data |
|---|---|
| Voltage-Gated Potassium Channel Ab, CSF | 0.0-1.1 pmol/L: Negative 1.2 pmol/L or greater: Positive |
Laboratory Developed Test (LDT)
Note
If NMDA CSF antibody IgG is positive, then a NMDA CSF antibody IgG titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then an AMPA CSF antibody IgG titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then a GABA-BR CSF antibody IgG titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then CASPR2 CSF antibody IgG titer will be added. Additional charges apply.
PCCA/ANNA CSF antibodies are screened by IFA. If the IFA screen is indeterminate then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then LGI1 CSF antibody IgG titer will be added. Additional charges apply.
If CV2.1 CSF antibody IgG is positive, then a CV2.1 CSF antibody IgG titer will be added. Additional charges apply.
If DPPX CSF antibody IgG by IFA is positive, then DPPX CSF antibody IgG titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86255 x8; 83519; 86341; 84182 x2; if reflexed, add 84182 x4; 86256 per titer
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005165 | N-methyl-D-Aspartate Receptor Ab, CSF | 80220-7 |
| 2010842 | Paraneoplastic Abs (PCCA/ANNA) IgG, CSF | 14247-1 |
| 3001258 | AMPA Receptor Ab IgG Screen, CSF | 82732-9 |
| 3001268 | GABA-B Receptor Ab IgG Screen, CSF | 82984-6 |
| 3001388 | Voltage-Gated Potassium Channel Ab, CSF | 68913-3 |
| 3001987 | CASPR2 Ab IgG Screen by IFA, CSF | 90820-2 |
| 3001991 | LGI1 Ab IgG Screen by IFA, CSF | 90830-1 |
| 3002259 | CV2.1 Ab IgG Screen, CSF | 53707-6 |
| 3002789 | Glutamic Acid Decarboxylase Antibody CSF | 42501-7 |
| 3002904 | SOX1 Antibody, IgG by Immunoblot, CSF | 94383-7 |
| 3004511 | Amphiphysin Antibody, CSF | 57750-2 |
| 3004513 | DPPX Ab IgG CBA IFA Screen, CSF | 94283-9 |
Aliases
- Dementia antibody panel
- Encephalitis antibody panel
- Epilepsy antibody panel
- Movement Disorders antibody panel
- Paraneoplastic antibody panel
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