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SOX1 Antibody, IgG by Immunoblot, CSF
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Ordering Recommendation
Consider ordering for individuals with Lambert-Eaton myasthenic syndrome (LEMS), paraneoplastic cerebellar degeneration (PCD), or paraneoplastic and nonparaneoplastic neuronopathy. May aid in the diagnosis of occult tumor, recurrence of tumor, or second tumor. Serum is the preferred specimen type; see SOX1 Antibody, IgG by Immunoblot, Serum (3002885).
Mnemonic
Methodology
Qualitative Immunoblot
Performed
Mon, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
CSF
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.60 mL)
Refrigerated.
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
Negative
Interpretive Data
SOX1 antibody is detected in patients with Lambert-Eaton myasthenic syndrome (LEMS) and in patients with paraneoplastic cerebellar degeneration (PCD), paraneoplastic and nonparaneoplastic neuropathy. SOX1 antibody is associated with small cell lung cancer. A negative test result does not rule out a diagnosis of LEMS or other causes of paraneoplastic neurological syndrome.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
84182
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3002904 | SOX1 Antibody, IgG by Immunoblot, CSF | 94383-7 |
Aliases
- AGNA
- Anti-glial nuclear antibody
- Cerebellar degeneration
- Lambert-Eaton myasthenic syndrome
- LEMS
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