Consider ordering for individuals with Lambert-Eaton myasthenic syndrome (LEMS), paraneoplastic cerebellar degeneration (PCD), or paraneoplastic and nonparaneoplastic neuronopathy. May aid in the diagnosis of occult tumor, recurrence of tumor, or second tumor. Serum is the preferred specimen type; see SOX1 Antibody, IgG by Immunoblot, Serum (3002885).
Mon, Thu, Sat
New York DOH Approval Status
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.60 mL)
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
SOX1 antibody is detected in patients with Lambert-Eaton myasthenic syndrome (LEMS) and in patients with paraneoplastic cerebellar degeneration (PCD), paraneoplastic and nonparaneoplastic neuropathy. SOX1 antibody is associated with small cell lung cancer. A negative test result does not rule out a diagnosis of LEMS or other causes of paraneoplastic neurological syndrome.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|3002904||SOX1 Antibody, IgG by Immunoblot, CSF||94383-7|
- Anti-glial nuclear antibody
- Cerebellar degeneration
- Lambert-Eaton myasthenic syndrome