HLA Antibody Screen, Class I and Class II

3002850
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Example Reports
Negative
Positive

Ordering Recommendation

Use to detect HLA antibodies for solid organ and stem cell transplantation.

Mnemonic

HLAABSCN

Methodology

Multiplex Bead Assay

Performed

Varies

Reported

3-7 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Plain red.

Specimen Preparation

Transfer 5 mL serum to ARUP Standard Transport Tubes. (Min. 2 mL)
New York State Clients: Transfer 7 mL serum to ARUP Standard Transport Tubes. (Min. 3 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 month; Frozen: 2 years

Reference Interval

By report

Interpretive Data

Background Information for HLA Antibody Screen, Class I and Class II
Purpose: To detect HLA Class I and Class II IgG antibodies.
Analytical Sensitivity & Specificity: More sensitive than traditional lymphocyte cytotoxicity procedures.
Limitations: Only detects IgG antibody isotype; IgM antibodies are not detected. This test does not provide information on the specificities of the HLA antibodies detected.
Test Results: Results are reported as positive or negative for HLA Class I and Class II antibodies.
This test was developed and its performance characteristics determined by the H&I laboratory at the University of Utah Health under the accreditation guidelines from the American Society for Histocompatibility and Immunogenetics (ASHI). Some tests or reagents have not been cleared or approved by the FDA.

Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2022
X
N/A

CPT Codes

86828

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Components

Component Test Code* Component Chart Name LOINC
2002804 HLA Class I Antibody 72322-1
3002851 HLA Class II Antibody
3002908 HLA Antibody Screen Interpretation 62364-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Histocompatibility testing
  • PRA
HLA Antibody Screen, Class I and Class II