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HLA Antibody Screen, Class I and Class II
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Ordering Recommendation
Use to detect HLA antibodies for solid organ and stem cell transplantation.
Mnemonic
Methodology
Multiplex Bead Assay
Performed
Varies
Reported
3-7 days
New York DOH Approval Status
Specimen Required
Plain red.
Transfer 5 mL serum to ARUP Standard Transport Tubes. (Min. 2 mL)
Refrigerated
Ambient: 72 hours; Refrigerated: 1 month; Frozen: 2 years
Reference Interval
By report
Interpretive Data
Background Information for HLA Antibody Screen, Class I and Class II
Purpose: To detect HLA Class I and Class II IgG antibodies.
Analytical Sensitivity & Specificity: More sensitive than traditional lymphocyte cytotoxicity procedures.
Limitations: Only detects IgG antibody isotype; IgM antibodies are not detected. This test does not provide information on the specificities of the HLA antibodies detected.
Test Results: Results are reported as positive or negative for HLA Class I and Class II antibodies.
This test was developed and its performance characteristics determined by the H&I laboratory at the University of Utah Health under the accreditation guidelines from the American Society for Histocompatibility and Immunogenetics (ASHI). Some tests or reagents have not been cleared or approved by the FDA.
Performed by non-ARUP Laboratory
Note
Hotline History
CPT Codes
86828
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2002804 | HLA Class I Antibody | 72322-1 |
| 3002851 | HLA Class II Antibody | |
| 3002908 | HLA Antibody Screen Interpretation | 62364-5 |
Aliases
- Histocompatibility testing
- PRA
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