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Autoimmune Encephalitis Reflexive Panel, CSF
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Ordering Recommendation
Differential evaluation of encephalitis of unknown origin with subacute onset of seizures, confusion, memory loss, and/or behavioral change. Serum is the preferred specimen; refer to Autoimmune Encephalitis Reflexive Panel, Serum (2013601). For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended; refer to Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF (2010841).
Mnemonic
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
CSF
Transfer three (3) 1 mL CSF aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Frozen.
Contaminated specimens.
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
||||
|---|---|---|---|---|---|---|
| 3002788 | Glutamic Acid Decarboxylase Antibody, CSF | 0.0-5.0 IU/mL | ||||
| 2005164 | N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer | Effective May 21, 2012 < 1:1 |
||||
| 2011699 | Aquaporin-4 Receptor Antibody, IgG by IFA, CSF with Reflex to Titer | less than 1:1 | ||||
| 3001257 | Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF | Less than 1:1 | ||||
| 3001267 | Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF | Less than 1:1 | ||||
| 3001387 | Voltage-Gated Potassium Channel (VGKC) Antibody, CSF |
|
||||
| 3001986 | Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, CSF | Less than 1:1 | ||||
| 3001992 | Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, CSF | Less than 1:1 |
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.
If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply.
If Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF IgG is positive, then an Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody Titer, IgG, CSF is reported. Additional charges apply.
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, CSF is performed. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86255 x6; 83519; 86341; if reflexed, add 86256 x6
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005165 | N-methyl-D-Aspartate Receptor Ab, CSF | 80220-7 |
| 2011700 | Neuromyelitis Optica/AQP4-IgG, CSF | 46718-3 |
| 3001258 | AMPA Receptor Ab IgG Screen, CSF | 82732-9 |
| 3001268 | GABA-B Receptor Ab IgG Screen, CSF | 82984-6 |
| 3001388 | Voltage-Gated Potassium Channel Ab, CSF | 68913-3 |
| 3001987 | CASPR2 Ab IgG Screen by IFA, CSF | 90820-2 |
| 3001991 | LGI1 Ab IgG Screen by IFA, CSF | 90830-1 |
| 3002789 | Glutamic Acid Decarboxylase Antibody CSF | 42501-7 |
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