Ordering Recommendation

Differential evaluation of encephalitis of unknown origin with subacute onset of seizures, confusion, memory loss, and/or behavioral change. Serum is the preferred specimen; refer to Autoimmune Encephalitis Reflexive Panel, Serum (2013601). For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended; refer to Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF (2010841).

Mnemonic

AENCEPHCSF

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF

Specimen Preparation

Transfer three (3) 1 mL CSF aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Contaminated specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
  Glutamic Acid Decarboxylase Antibody CSF 0.0-5.0 IU/mL
  N-methyl-D-Aspartate Receptor Ab, CSF Less than 1:1
  Neuromyelitis Optica/AQP4-IgG, CSF Less than 1:1
  AMPA Receptor Ab IgG Screen, CSF Less than 1:1
  GABA-B Receptor Ab IgG Screen, CSF Less than 1:1
  Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L
  CASPR2 Ab IgG Screen by IFA, CSF Less than 1:1
  LGI1 Ab IgG Screen by IFA, CSF Less than 1:1
  DPPX Ab IgG CBA IFA Screen, CSF Less than 1:1

Interpretive Data

Refer to report.


Component
Interpretive Data
Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L: Negative
1.2 pmol/L or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

If NMDA CSF antibody IgG is positive, then a NMDA CSF antibody IgG titer will be added. Additional charges apply.
If AQP4 CSF antibody IgG is positive, then an AQP4 CSF antibody IgG titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then an AMPA CSF antibody IgG titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then a GABA-BR CSF antibody IgG titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then CASPR2 CSF antibody IgG titer will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then LGI1 CSF antibody IgG titer will be added. Additional charges apply.
If DPPX CSF antibody IgG is positive, then DPPX CSF antibody IgG titer will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

86052; 86255 x6; 83519; 86341; if reflexed, add 86256 per titer.

Components

Component Test Code* Component Chart Name LOINC
2005165 N-methyl-D-Aspartate Receptor Ab, CSF 80220-7
2011700 Neuromyelitis Optica/AQP4-IgG, CSF 46718-3
3001258 AMPA Receptor Ab IgG Screen, CSF 82732-9
3001268 GABA-B Receptor Ab IgG Screen, CSF 82984-6
3001388 Voltage-Gated Potassium Channel Ab, CSF 68913-3
3001987 CASPR2 Ab IgG Screen by IFA, CSF 90820-2
3001991 LGI1 Ab IgG Screen by IFA, CSF 90830-1
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
3004513 DPPX Ab IgG CBA IFA Screen, CSF 94283-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Autoimmune Encephalitis Reflexive Panel, CSF