Acute Myeloid Leukemia Mutation Panel by Next Generation Sequencing

3002714
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Example Reports
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Additional Technical Information

Ordering Recommendation

Use to assess for single gene mutations, including substitutions and smaller insertions and deletions, that may have prognostic and/or therapeutic significance in acute myeloid leukemia (AML). 

Mnemonic

AML NGS

Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

12-14 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), Green (sodium heparin) Bone Marrow (EDTA) or Bone Marrow (sodium heparin), Fresh-frozen tissue.

Specimen Preparation

Whole Blood and Bone Marrow: Transport 3 mL. (Min: 1.5 mL)
Fresh-frozen Tissue: Transport 5 mg fresh-frozen tissue.
Separate specimens must be submitted when multiple tests are ordered

Storage/Transport Temperature

Whole Blood or Bone Marrow: Refrigerated.
Fresh-frozen Tissue: Frozen.

Unacceptable Conditions

Serum, plasma, grossly hemolyzed specimens, buccal brush or swab, FFPE tissue

Remarks
Stability

Whole Blood or Bone Marrow: Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Fresh-frozen Tissue: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval

By report

Interpretive Data

Refer to report.    

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: ANKRD26, ASXL1, CEBPA, DDX41, DNMT3A, ETV6, FLT3, GATA2, IDH1, IDH2, KIT, KRAS, NPM1*, NRAS, RUNX1, TP53, WT1
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/16/2021
X
N/A

CPT Codes

81450

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Components

Component Test Code* Component Chart Name LOINC
3002715 Acute Myeloid Leukemia Specimen
3002716 Acute Myeloid Leukemia Interp
3002718 EER, AML Panel by NGS 11502-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Acute Myeloid Leukemia Mutation Panel by Next Generation Sequencing