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Hereditary Melanoma Panel, Sequencing and Deletion/Duplication
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Ordering Recommendation
Recommended test to confirm a hereditary cause of melanoma in individuals with a personal or family history of disease. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
To compare this test to other hereditary cancer panels, refer to the ARUP Hereditary Cancer Panel Comparison table.
Mnemonic
Methodology
Massively Parallel Sequencing/Sequencing
Performed
Varies
Reported
Within 21 days
New York DOH Approval Status
Specimen Required
Lavender or pink (EDTA) or yellow (ACD solution A or B).
Transport 3 mL whole blood. (Min: 2 mL)
Refrigerated.
Serum or plasma; grossly hemolyzed or frozen specimens; saliva; buccal brush, or swab; FFPE tissue.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
GENES TESTED: BAP1; BRCA2; CDK4; CDKN2A*; MC1R; MITF*; POT1; PTEN*; RB1*; TERT; TP53
*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
Hotline History
Hotline History
CPT Codes
81167; 81216; 81404; 81321; 81323; 81351; 81479
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3006063 | MELCAN Specimen | 66746-9 |
| 3006064 | MELCAN Interp | 50398-7 |
Aliases
- BRCA
- Cowden syndrome
- Dyskeratosis congenita
- FAMMM syndrome
- Hereditary retinoblastoma
- Li-Fraumeni syndrome
- Melanoma, Familial melanoma, Familial atypical multiple mole melanoma
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