Ordering Recommendation

Aids in the diagnosis of renal cell carcinoma (RCC) and alveolar soft part sarcoma (ASPS).

Mnemonic
TFE3_FISH
Methodology

Fluorescence in situ Hybridization

Performed

Mon-Fri

Reported

3-7 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (4- micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808), available online through eSupply using ARUP Connector contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min: 2 slides)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

88366

Components
Component Test Code* Component Chart Name LOINC
3000703 Scoring Method 81304-8
3002634 TFE3 Ref Number 80398-1
3002635 TFE3 Source 31208-2
3002636 TFE3 Result 35474-6
3002953 Total Cell Count 78236-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
TFE3 Gene Rearrangement by FISH