Ordering Recommendation

Aids in the diagnosis of renal cell carcinoma (RCC) and alveolar soft part sarcoma (ASPS).

Mnemonic

TFE3_FISH

Methodology

Fluorescence in situ Hybridization

Performed

Mon-Fri

Reported

3-7 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (4- micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808), available online through eSupply using ARUP Connector contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min: 2 slides)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

88366

Components

Component Test Code* Component Chart Name LOINC
3000703 Scoring Method 81304-8
3002634 TFE3 Ref Number 80398-1
3002635 TFE3 Source 31208-2
3002636 TFE3 Result 35474-6
3002953 Total Cell Count 78236-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

TFE3 Gene Rearrangement by FISH