Ordering Recommendation

Use to optimize drug therapy and monitor patient adherence.

Mnemonic
CLOBAZAM
Methodology

Quantitative High Performance Liquid Chromatography/Tandem Mass Spectrometry

Performed

Mon, Wed, Sat

Reported

1-4 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Plain Red, Lavender (K2 or K3EDTA) or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within two hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Gel separator tubes. Hemolyzed specimens.

Remarks
Stability

Ambient: 3 days; Refrigerated: 2 weeks; Frozen: 2 months (Avoid repeated freeze thaw cycles)

Reference Interval

By report

Available Seperately
Components
Theraputic and Toxic Range
No Clobazam Therapeutic Range: 30 - 300 ng/mL
Toxic: Greater than 500 ng/mL
No N-Desmethylclobazam Therapeutic Range: 300 - 3000 ng/mL
Toxic: Greater than 5000 ng/mL

Interpretive Data

Clobazam is a benzodiazepine drug indicated for adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients 2 years and older.  The therapeutic range is based on serum, pre-dose (trough) draw collection at steady-state concentration. The pharmacokinetics of clobazam are influenced by drug-drug interactions and by poor CYP2C19 metabolism. Adverse effects may include constipation, somnolence, sedation, and skin rash. The concomitant use of clobazam with other central nervous system (CNS) depressants may increase the risk of somnolence and sedation.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80339 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
3002509 Clobazam 3487-6
3002510 N-Desmethylclobazam 35107-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Onfi
  • Sympazan
Clobazam and Metabolite, Quantitative, Serum or Plasma