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Anti-sp100 Antibody, IgG
Ordering Recommendation
Recommended for the evaluation of individuals with suspected primary biliary cholangitis (PBC) who test negative for anti-mitochondrial antibodies (AMA).
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to ARUP Standard Transport Tube. (Min: 0.1 mL)
Refrigerated
Non-Serum, heat-inactivated, contaminated, grossly icteric, severely lipemic, grossly hemolyzed specimens or inclusion of fibrin clot.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Wed
Reported
1-8 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Anti-sp100 Antibody, IgG | 24.9 Units or less |
Interpretive Data
SP100 IgG antibodies can be detected in patients with primary biliary cholangitis (PBC) and may be of diagnostic relevance in a subset of patients with PBC who are negative for anti-mitochondrial antibodies (AMA). These antibodies have a relatively low sensitivity with excellent specificity for PBC. A negative result does not rule out PBC.
| Component | Interpretation |
|---|---|
| Anti-sp100 Antibody, IgG | 20.1 Units or less Negative 20.1-24.9 Units Equivocal 25.0 Units or greater Positive |
FDA
Note
Hotline History
CPT Codes
83516
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3002484 | Anti-sp100 Antibody, IgG | 96560-8 |
