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Thyroid Stimulating Immunoglobulin
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Ordering Recommendation
Acceptable test secondary for autoimmune thyroid disease.
Mnemonic
Methodology
Semi-Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST), Green (Lithium Heparin), or Lavender (K EDTA).
Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Frozen.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 year
Reference Interval
| 0.54 IU/L or less | Consistent with healthy thyroid function or non-Graves thyroid or autoimmune disease. Those with healthy thyroid function typically have results less than 0.1 IU/L. |
| 0.55 IU/L or greater | Consistent with Graves disease (autoimmune hyperthyroidism). |
Interpretive Data
This assay specifically detects thyroid stimulating autoantibodies. For diagnostic purposes, the results obtained from this assay should be used in combination with clinical examination, patient medical history, and other findings.
FDA
Note
Hotline History
CPT Codes
84445
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3002288 | Thyroid Stimulating Immunoglobulin-TSI | 30567-2 |
Aliases
- Autoimmune Thyroid Stimulator
- Thyroid Stimulating Antibody
- Thyroid-Stimulating Immunoglobulin Serum
- TSI
- TSI concentration
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