IDH1 R132H Point Mutation by Immunohistochemistry with Reflex to IDH1 and IDH2 Mutation Analysis, Exon 4
Identify the most common IDH mutation in diffuse gliomas. Negative results reflexes to IDH1 and IDH2 Mutation Analysis, Exon 4 (2006444) to assess for less common IDH mutations.
1-5 days, add 8-14 days if reflexed
Formalin fix (10 percent neutral buffered formalin is preferred) and paraffin embed specimen. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 7 unstained (5-micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800)522-2787. (Min. 4 slides) If sending precut slides, do not oven bake.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Paraffin block with less than 25 percent tumor tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.
Include surgical pathology report.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
Laboratory Developed Test (LDT)
This test code includes pathologist interpretation.
Negative IHC results will reflex to IDH1 and IDH2 Mutation Analysis, Exon 4, to assess for less common IDH mutations. Additional charges apply.
88342, if reflexed add 88381; 81120; 81121
|Component Test Code*||Component Chart Name||LOINC|
|3002136||IDH1 R132H Point Mut by IHC with Reflex|
|3003120||IDH1 Tissue Source|
- Astrocytoma and Oligodendroglioma Tumor Cell Marker
- IDH1 Point mutation IHC
- IDH1 R132H antibody staining
- IDH1 R132H IHC, Isocitrate dehydrogenase