Ordering Recommendation

Detect antibodies for P/Q type and N-type voltage-gated calcium channels. Aid in the evaluation of muscle weakness in the context neuromuscular junction disorder with or without cancer, or the diagnosis of paraneoplastic neurological syndromes.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain Red or Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL to an ARUP Standard Transport Tube. (Min.: 0.2 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed or grossly lipemic specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Quantitative Radioimmunoassay




2-9 days

Reference Interval

Test Number
Reference Interval
  N-Type Calcium Channel Antibody 69.9 pmol/L or less
  P/Q-Type Calcium Channel Antibody 24.5 pmol/L or less

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Interpretive Data
N-Type Calcium Channel Antibody 0.0 to 69.9 pmol/L: Negative
70.0 to 110.0 pmol/L: Indeterminate
100.1 pmol/L or greater: Positive
Voltage-Gated Calcium Channel (VGCC) Ab 0.0 to 24.5 pmol/L: Negative
24.6 to 45.6 pmol/L: Indeterminate
45.7 pmol/L or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

86596 x2


Component Test Code* Component Chart Name LOINC
0092629 P/Q-Type Calcium Channel Antibody 33980-4
3002047 N-Type Calcium Channel Antibody 33979-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Lambert Eaton
  • Lambert-Eaton
  • N calcium channel
  • N VGCC Ab
  • P/Q calcium channel
  • VGCC Ab
Voltage-Gated Calcium Channel (VGCC) Antibody Panel