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Voltage-Gated Calcium Channel (VGCC) Antibody Panel
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Ordering Recommendation
Detect antibodies for P/Q type and N-type voltage-gated calcium channels. Aid in the evaluation of muscle weakness in the context neuromuscular junction disorder with or without cancer, or the diagnosis of paraneoplastic neurological syndromes.
Mnemonic
Methodology
Quantitative Radioimmunoassay
Performed
Tue
Reported
2-9 days
New York DOH Approval Status
Specimen Required
Plain Red or Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL to an ARUP Standard Transport Tube. (Min.: 0.2 mL)
Refrigerated.
Hemolyzed or grossly lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| N-Type Calcium Channel Antibody | 69.9 pmol/L or less | |
| P/Q-Type Calcium Channel Antibody | 24.5 pmol/L or less |
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
| Component |
Interpretive Data |
|---|---|
| N-Type Calcium Channel Antibody | 0.0 to 69.9 pmol/L: Negative 70.0 to 110.0 pmol/L: Indeterminate 100.1 pmol/L or greater: Positive |
| Voltage-Gated Calcium Channel (VGCC) Ab | 0.0 to 24.5 pmol/L: Negative 24.6 to 45.6 pmol/L: Indeterminate 45.7 pmol/L or greater: Positive |
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
86596 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092629 | P/Q-Type Calcium Channel Antibody | 33980-4 |
| 3002047 | N-Type Calcium Channel Antibody | 33979-6 |
Aliases
- Lambert Eaton
- Lambert-Eaton
- N calcium channel
- N VGCC Ab
- P/Q calcium channel
- VGCC Ab
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