Contactin-Associated Protein-2 (CASPR2) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Ordering Recommendation
Aids in diagnosis of contactin-associated protein-2 (CASPR2) antibody disorders associated with acquired neuromyotonia, limbic encephalitis, painful neuropathy, and Morvan syndrome. Use to manage antibody-positive (CASPR2) individuals following immunotherapy and/or plasmapheresis. Serum is the preferred specimen; refer to Contactin-Associated Protein-2 Antibody, IgG CBA-IFA with Reflex to Titer, Serum (2009452).
New York DOH Approval Status
Specimen Required
CSF.
Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.15 mL)
Refrigerated.
Contaminated, hemolyzed, or severely lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Methodology
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody
Performed
Wed
Reported
1-8 days
Reference Interval
Less than 1:1
Interpretive Data
Contactin-associated protein-2 (CASPR2) IgG antibody may occur as part of the voltage-gated potassium channel (VGKC) complex antibodies.
The presence of CASPR2 IgG antibody is associated with a wide spectrum of clinical manifestations, including acquired neuromyotonia, limbic encephalitis, painful neuropathy, and Morvan syndrome. Tumors such as thymoma, small cell lung cancer, and other rarer tumors may occur. The full spectrum of clinical disorders and tumors associated with the CASPR2 IgG antibody continues to be defined. Results should be interpreted in correlation with the patient's clinical history and other laboratory findings.
This indirect fluorescent antibody assay utilizes CASPR2 transfected cell lines for the detection and semiquantification of the CASPR2 IgG antibody.
Laboratory Developed Test (LDT)
Note
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86255; if reflexed, add 86256
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3001987 | CASPR2 Ab IgG CBA-IFA Screen, CSF | 90820-2 |