Ordering Recommendation

May aid in the evaluation of lung inflammation or injury in various types of interstitial lung disease (ILD).


Quantitative Enzyme-Linked Immunosorbent Assay




1-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Plain Red.

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Reference Interval

1-300 ng/mL

Interpretive Data

Human Surfactant Protein D (SP-D) is a non-specific indicator of lung inflammation or damage. Elevated levels are associated with various types of interstitial lung diseases (ILD).

Abnormal SP-D results should be interpreted in the appropriate clinical context. A negative result does not rule out ILD.

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code* Component Chart Name LOINC
3001970 Human Surfactant Protein D 74541-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Human Surfactant Protein D (SP-D)