Ordering Recommendation

Secondary test to diagnose autoimmune disease after adrenal insufficiency confirmed.

Mnemonic
21OH AB
Methodology

Qualitative Enzyme-Linked Immunosorbent Assay

Performed

Tue, Fri

Reported

2-7 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST) or Plain Red.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

Negative

Interpretive Data

The 21-Hydroxylase Autoantibody assay is intended for the qualitative determination of autoantibodies to steroid 21-hydroxylase in human serum.
A positive result is indicative of primary adrenal insufficiency (Addison disease). Results should be interpreted within the context of clinical symptoms, including functional adrenal testing.
Males with adrenal insufficiency and negative results for 21-hydroxylase autoantibodies should be screened for X-Linked Adrenoleukodystrophy (X-ALD) by ordering Very Long-Chain Branched Fatty Acids in Plasma (ARUP Test Code 2004250). 

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
3001963 21-Hydroxylase Autoantibody 85363-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 21-OH Ab
  • Adrenal Antibodies
  • Adrenal Antibody
  • Anti-Adrenal Antibody
  • Hydroxylase Antibody
21-Hydroxylase Autoantibodies, Serum