Ordering Recommendation

Germline analysis of the BRCA1 and BRCA2 genes in individuals with a suspected diagnosis of hereditary breast and ovarian cancer (HBOC) syndrome. When a relative has a previously identified pathogenic sequence variant, see Familial Mutation, Targeted Sequencing (2001961).

Mnemonic
BRCA NGS
Methodology

Massively Parallel Sequencing/Multiplex Ligation-dependent Probe Amplification

Performed

Varies

Reported

15-17 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.  

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: BRCA1 (NM_007294), BRCA2 (NM_000059)

Hotline History
N/A
CPT Codes

81162

Components
Component Test Code* Component Chart Name LOINC
3001861 BRCA Specimen 31208-2
3001862 BRCA Interp 94191-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Hereditary Breast
  • Ovarian Cancer
BRCA1 and BRCA2-Associated HBOC Syndrome Panel, Sequencing and Deletion/Duplication