Ordering Recommendation

Recommended test to confirm BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) syndrome. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.

Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

5-10 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: BRCA1* (NM_007294), BRCA2 (NM_000059)
*One or more exons are not covered by deletion/duplication analysis for the indicated gene; see Additional Technical Information.

Hotline History

N/A

CPT Codes

81162

Components

Component Test Code* Component Chart Name LOINC
3001861 BRCA Specimen 31208-2
3001862 BRCA Interp 94191-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Hereditary Breast
  • Ovarian Cancer
BRCA1 and BRCA2-Associated HBOC Syndrome Panel, Sequencing and Deletion/Duplication