BRCA1 and BRCA2-Associated HBOC Syndrome Panel, Sequencing and Deletion/Duplication
Ordering Recommendation
Recommended test to confirm BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) syndrome. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.
Mnemonic
Methodology
Massively Parallel Sequencing
Performed
Varies
Reported
15-17 days
New York DOH Approval Status
Specimen Required
Lavender or pink (EDTA) or yellow (ACD solution A or B).
Transport 3 mL whole blood. (Min: 2 mL)
Refrigerated.
Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
Genes tested: BRCA1* (NM_007294), BRCA2 (NM_000059)
*One or more exons are not covered by deletion/duplication analysis for the indicated gene; see Additional Technical Information.
Hotline History
Hotline History
CPT Codes
81162
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3001861 | BRCA Specimen | 31208-2 |
3001862 | BRCA Interp | 94191-4 |
Aliases
- Hereditary Breast
- Ovarian Cancer