BRCA1 and BRCA2-Associated HBOC Syndrome Panel, Sequencing and Deletion/Duplication

3001855
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Patient History Form for Hereditary Breast and Gynecological Cancer

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Additional Technical Information

Ordering Recommendation

Recommended test to confirm BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) syndrome. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.

Mnemonic

BRCA NGS

Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

15-17 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: BRCA1* (NM_007294), BRCA2 (NM_000059)
*One or more exons are not covered by deletion/duplication analysis for the indicated gene; see Additional Technical Information.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
04/04/2022
X
X
X
X
N/A

CPT Codes

81162

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Components

Component Test Code* Component Chart Name LOINC
3001861 BRCA Specimen 31208-2
3001862 BRCA Interp 94191-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Hereditary Breast
  • Ovarian Cancer
BRCA1 and BRCA2-Associated HBOC Syndrome Panel, Sequencing and Deletion/Duplication