Ordering Recommendation

Glutamate dehydrogenase (GDH) antigen and toxin A/B testing for suspected Clostridioides (Clostridium) difficile infection, with reflex to nucleic acid amplification test (PCR).

Mnemonic
CDIFF LFA
Methodology

Qualitative Enzyme Immunoassay/Qualitative Polymerase Chain Reaction

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Stool.

Specimen Preparation

Transfer 5g stool to a clean, unpreserved transport vial (ARUP Supply# 40910) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1g)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Specimens preserved in Cary Blair/C&S media, formalin-based fixative (eg, Formalin, SAF) or alcohol-based fixative (eg, PVA, Totalfix, Alcorfix, etc).

Remarks
Stability

Ambient 2 hours; Refrigerated 72 hours; Frozen 2 weeks

Reference Interval

Not Detected

Interpretive Data

Refer to report

No compliance statements are in use for this test.

Note

If C. difficile GDH antigen is detected by LFA but C. difficile toxin is not detected, C. difficile tcdB gene by PCR will be performed, additional charges apply.

Hotline History
N/A
CPT Codes

87324, 87449; if reflexed add 87493

Components
Component Test Code* Component Chart Name LOINC
3001805 Toxigenic C. difficile Interpretation 34712-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • C diff
  • C diff antigen
  • C diff toxin
  • Cdiff
  • Clostridioides difficle
  • Clostridium difficile
Toxigenic Clostridium difficile by LFA with Reflex to PCR, Stool