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Toxigenic Clostridium difficile by LFA with Reflex to PCR, Stool
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Ordering Recommendation
Glutamate dehydrogenase (GDH) antigen and toxin A/B testing for suspected Clostridioides (Clostridium) difficile infection, with reflex to nucleic acid amplification test (PCR).
Mnemonic
Methodology
Qualitative Enzyme Immunoassay/Qualitative Polymerase Chain Reaction
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Liquid or soft stool.
Transfer 1.0 mL stool to a clean, unpreserved transport vial (ARUP Supply# 40910). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL).
Refrigerated. Also acceptable: Frozen.
Specimens preserved in Cary Blair/C&S media, formalin-based fixative (eg, Formalin, SAF) or alcohol-based fixative (eg, PVA, Totalfix, Alcorfix, etc).
Ambient 2 hours; Refrigerated 72 hours; Frozen 1 week
Reference Interval
Not Detected
Interpretive Data
Refer to report
FDA
Note
If C. difficile GDH antigen is detected by LFA but C. difficile toxin is not detected, C. difficile tcdB gene by PCR will be performed, additional charges apply.
Hotline History
CPT Codes
87324; 87899; if reflexed, add 87493
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3001805 | Toxigenic C. difficile Interpretation | 34712-0 |
Aliases
- C diff
- C diff antigen
- C diff toxin
- Cdiff
- Clostridioides difficle
- Clostridium difficile
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