Ordering Recommendation

Glutamate dehydrogenase (GDH) antigen and toxin A/B testing for suspected Clostridioides (Clostridium) difficile infection, with reflex to polymerase chain reaction (PCR).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Liquid or soft stool.

Specimen Preparation

Transfer 1.0 mL stool to a clean, unpreserved transport vial (ARUP Supply# 40910). Available online through eSupply using ARUP Connect (TM) or contact ARUP Client Services at 800-522-2787. (Min: 0.5 mL).

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Specimens preserved in Cary Blair/C&S media, formalin-based fixative (eg, Formalin, SAF) or alcohol-based fixative (eg, PVA, Totalfix, Alcorfix, etc). Formed stool.


Ambient 2 hours; Refrigerated 72 hours; Frozen 1 week


Qualitative Lateral Flow Immunoassay/Qualitative Polymerase Chain Reaction (PCR)




Within 24 hours

Reference Interval

Not Detected

Interpretive Data

Refer to report

Compliance Category



If C. difficile GDH antigen is detected by LFA but C. difficile toxin is not detected, C. difficile tcdB gene by PCR will be performed; additional charges apply.

Hotline History


CPT Codes

87324; 87899; if reflexed, add 87493


Component Test Code* Component Chart Name LOINC
3001805 Toxigenic C. difficile Interpretation 34712-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • C diff
  • C diff antigen
  • C diff toxin
  • Cdiff
  • Clostridioides difficle
  • Clostridium difficile
Toxigenic Clostridioides difficile by LFA with Reflex to PCR, Stool