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Interstitial Lung Disease Autoantibody Panel
Copy Utility
Ordering Recommendation
May be useful for evaluation of interstitial lung disease in the context of systemic autoimmune rheumatic disease (ie, connective tissue disease).
Mnemonic
Methodology
Qualitative Immunoprecipitation/Semi-Quantitative Multiplex Bead Assay/Qualitative Immunoblot/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Quantitative Immunoturbidimetry
Performed
Sun-Sat
Reported
7-18 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer five 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Refrigerated.
Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.
Ambient: 24 hours; Refrigerated: 1 weeks; Frozen: 1 month
Reference Interval
| Test Number |
Components |
Reference Interval |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012074 | SSA 52 and 60 (Ro) (ENA) Antibodies, IgG |
|
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| 0050599 | Scleroderma (Scl-70) (ENA) Antibody, IgG |
|
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| 0099592 | Jo-1 Antibody, IgG |
|
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| 2003040 | PM/Scl-100 Antibody, IgG by Immunoblot | Negative | |||||||||
| 0050465 | Rheumatoid Factor | 0-14 IU/mL | |||||||||
| 0055256 | Cyclic Citrullinated Peptide (CCP) Antibody, IgG |
|
|||||||||
| 3000082 | Antinuclear Antibody (ANA) with HEp-2 Substrate, IgG by IFA | Less than 1:80 | |||||||||
| 2001601 | RNA Polymerase III Antibody, IgG |
|
|||||||||
| PL-7 (threonyl-tRNA synthetase) Antibody | Negative | ||||||||||
| PL-12 (alanyl-tRNA synthetase) Antibody | Negative | ||||||||||
| EJ (glycyl-tRNA synthetase) Antibody | Negative | ||||||||||
| Ku Antibody | Negative | ||||||||||
| SRP (Signal Recognition Particle) Ab | Negative | ||||||||||
| OJ (isoleucyl-tRNA synthetase) Antibody | Negative | ||||||||||
| NXP2 (Nuclear matrix protein-2) Ab | Negative | ||||||||||
| MDA5 (CADM-140) Ab | Negative |
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Antibodies: Ro52, Ro60, Jo-1, PL-7, PL12, EJ, Ku, SRP, OJ, PM/Scl-100, MDA5, CCP, Scl-70, RA, ANA, NXP-2, RNA Polymerase III
Hotline History
Hotline History
CPT Codes
86235 x5; 83516 x7; 84182 x2; 86431; 86200; 86039
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050465 | Rheumatoid Factor | 11572-5 |
| 0050599 | Scleroderma (Scl-70) (ENA) Antibody, IgG | 47322-3 |
| 0050691 | SSA-52 (Ro52) (ENA) Antibody, IgG | 31625-7 |
| 0055256 | Cyclic Citrullinated Peptide Ab, IgG | 33935-8 |
| 0099592 | Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | 33571-1 |
| 2001602 | RNA Polymerase III Antibody, IgG | 79182-2 |
| 2003041 | PM/Scl 100 Antibody, IgG | 81732-0 |
| 2010853 | PL-7 (threonyl-tRNA synthetase) Antibody | 33772-5 |
| 2010854 | PL-12 (alanyl-tRNA synthetase) Antibody | 33771-7 |
| 2010856 | EJ (glycyl-tRNA synthetase) Antibody | 45149-2 |
| 2010857 | Ku Antibody | 18484-6 |
| 2010859 | SRP (Signal Recognition Particle) Ab | 33921-8 |
| 2010860 | OJ (isoleucyl-tRNA synthetase) Antibody | 45152-6 |
| 2012055 | SSA-60 (Ro60) (ENA) Antibody, IgG | 53019-6 |
| 2013998 | Interpretive Information | 48767-8 |
| 3000090 | Antinuclear Antibody (ANA), HEp-2, IgG | 21424-7 |
| 3000096 | ANA Interpretive Comment | 49311-4 |
| 3001787 | MDA5 (CADM-140) Ab | 82424-3 |
| 3001788 | NXP2 (Nuclear matrix protein-2) Ab | 82426-8 |
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