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Extended Myositis Panel
Copy Utility
Ordering Recommendation
May be useful for differential evaluation of polymyositis, dermatomyositis, necrotizing autoimmune myopathy, or overlap syndromes associated with connective tissue disease.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Qualitative Immunoprecipitation/Semi-Quantitative Multiplex Bead Assay/Qualitative Immunoblot
Performed
Sun-Sat
Reported
7-18 days
New York DOH Approval Status
Specimen Required
Serum separator tube (SST), red top tube
Separate from cells ASAP or within 2 hours of collection. Transfer three 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Refrigerated.
Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Smith/RNP (ENA) Ab, IgG | 19 Units or less |
|
| SSA-52 (Ro52) (ENA) Antibody, IgG | 40 AU/mL or less | |
| Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | 40 AU/mL or less |
|
| PM/Scl 100 Antibody, IgG | Negative | |
| Mi-2 (nuclear helicase protein) Antibody | Negative | |
| PL-7 (threonyl-tRNA synthetase) Antibody | Negative | |
| PL-12 (alanyl-tRNA synthetase) Antibody | Negative | |
| P155/140 Antibody | Negative | |
| EJ (glycyl-tRNA synthetase) Antibody | Negative | |
| Ku Antibody | Negative | |
| SRP (Signal Recognition Particle) Ab | Negative | |
| OJ (isoleucyl-tRNA synthetase) Antibody | Negative | |
| SSA-60 (Ro60) (ENA) Antibody, IgG | 40 AU/mL or less | |
| Fibrillarin (U3 RNP) Ab, IgG | Negative | |
| SAE1 (SUMO activating enzyme) Ab | Negative | |
| MDA5 (CADM-140) Ab | Negative | |
| NXP2 (Nuclear matrix protein-2) Ab | Negative | |
| TIF-1 gamma (155 kDa) Ab | Negative |
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
| Component |
Interpretation |
|---|---|
| SSA-52 (Ro52) (ENA) Antibody, IgG | 29 AU/mL or Less: Negative 30-40 AU/mL: Equivocal 41 AU/mL or greater: Positive |
| SSA-60 (Ro60) (ENA) Antibody, IgG | 29 AU/mL or Less: Negative 30-40 AU/mL: Equivocal 41 AU/mL or greater: Positive |
| Smith/RNP (ENA) Antibody, IgG | 19 Units or less Negative 20-39 Units Weak Positive 40-80 Units Moderate Positive 81 Units or greater Strong Positive |
| Jo-1 Antibody, IgG | 29 AU/mL or less Negative 30-40 AU/mL Equivocal 41 AU/mL or greater Positive |
Laboratory Developed Test (LDT)
Note
Antibodies: Mi-2, PL-7, PL12, P155/140, EJ, Ku, OJ, PM/Scl, SRP, Smith/RNP, Ro52, Ro60, Jo-1, U3 Fib, SAE1, NXP2, MDA5, TIF1-gamma
Hotline History
Hotline History
CPT Codes
83516 x8; 86235 x6; 84182 x4
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050470 | Smith/RNP (ENA) Ab, IgG | 33983-8 |
| 0050691 | SSA-52 (Ro52) (ENA) Antibody, IgG | 31625-7 |
| 0099592 | Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | 33571-1 |
| 2003041 | PM/Scl 100 Antibody, IgG | 81732-0 |
| 2010852 | Mi-2 (nuclear helicase protein) Antibody | 18485-3 |
| 2010853 | PL-7 (threonyl-tRNA synthetase) Antibody | 33772-5 |
| 2010854 | PL-12 (alanyl-tRNA synthetase) Antibody | 33771-7 |
| 2010855 | P155/140 Antibody | 8061-4 |
| 2010856 | EJ (glycyl-tRNA synthetase) Antibody | 45149-2 |
| 2010857 | Ku Antibody | 18484-6 |
| 2010859 | SRP (Signal Recognition Particle) Ab | 33921-8 |
| 2010860 | OJ (isoleucyl-tRNA synthetase) Antibody | 45152-6 |
| 2012055 | SSA-60 (Ro60) (ENA) Antibody, IgG | 53019-6 |
| 2012174 | Fibrillarin (U3 RNP) Ab, IgG | 49963-2 |
| 2013994 | Myositis Panel Interpretive Data | 48767-8 |
| 3001786 | SAE1 (SUMO activating enzyme) Ab | 82440-9 |
| 3001787 | MDA5 (CADM-140) Ab | 82424-3 |
| 3001788 | NXP2 (Nuclear matrix protein-2) Ab | 82426-8 |
| 3001789 | TIF-1 gamma (155 kDa) Ab | 82448-2 |
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