Hereditary Central Nervous System Cancer Panel, Sequencing and Deletion/Duplication

3001633
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Hereditary Cancer Testing Patient History Form

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Additional Technical Information

Ordering Recommendation

Recommended test to confirm a hereditary cause of central nervous system (CNS) cancer in individuals with a personal or family history. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the ARUP Hereditary Cancer Panel Comparison table.

Mnemonic

CNSCAN NGS

Methodology

Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependent Probe Amplification

Performed

Varies

Reported

21-42 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: ALK; APC*; DICER1; EPCAM**; HRAS; LZTR1; MEN1*; MLH1; MSH2; MSH6; NF1; NF2; PMS2; POT1; PRKAR1A; PTCH1; PTEN*; RB1*; SMARCA4; SMARCB1; SMARCE1*; SUFU; TP53; TSC1; TSC2; VHL*

*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
N/A

CPT Codes

81201; 81203; 81403; 81404; 81405; 81406; 81407; 81408; 81479

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Components

Component Test Code* Component Chart Name LOINC
3006058 CNSCAN Specimen 66746-9
3006059 CNSCAN Interp 50398-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Familial adenomatous polyposis (FAP)
  • AFAP
  • Cowden syndrome
  • Gorlin syndrome
  • hereditary nonpolyposis colorectal cancer (HNPCC)
  • Li-Fraumeni syndrome (LFS)
  • Lynch syndrome
  • multiple endocrine neoplasia
  • neurofibromatosis
  • retinoblastoma
  • rhabdoid tumor predisposition syndrome
  • tuberous sclerosis complex
  • Von Hippel Lindau
Hereditary Central Nervous System Cancer Panel, Sequencing and Deletion/Duplication