Ordering Recommendation

Diagnostic and presymptomatic testing for individuals with a clinical suspicion for or a family history of Alzheimer’s disease diagnosed before age 65. A patient history form is required before testing will be performed. Informed consent is required for testing in presymptomatic adults. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Two Lavender (EDTA)

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)
New York State Clients: transport 8 mL (Min: 6mL) in two lavender (EDTA) tubes

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: Unacceptable
New York State Clients: Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable

Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

10-15 days

Reference Interval

By report

Interpretive Data

Refer to report. 

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: APP, PSEN1, PSEN2

Hotline History

N/A

CPT Codes

81405; 81406

Components

Component Test Code* Component Chart Name LOINC
3001586 Alzheimer's Interp 35474-6
3001672 Alzheimer's Specimen 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AD
  • dementia
  • familial Alzheimer's disease (FAD)
  • presenile dementia
Early-Onset Alzheimer's Panel, Sequencing