Ordering Recommendation

Diagnostic and presymptomatic testing for individuals with a clinical suspicion for or a family history of Alzheimer’s disease diagnosed before age 65. A patient history form is required before testing will be performed. Informed consent is required for testing in presymptomatic adults. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Two Lavender (EDTA)

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)
New York State Clients: transport 8 mL (Min: 6mL) in two lavender (EDTA) tubes

Storage/Transport Temperature


Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.


Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: Unacceptable
New York State Clients: Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable


Massively Parallel Sequencing




10-15 days

Reference Interval

By report

Interpretive Data

Refer to report. 

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


Genes tested: APP, PSEN1, PSEN2

Hotline History


CPT Codes

81405; 81406


Component Test Code* Component Chart Name LOINC
3001586 Alzheimer's Interp 35474-6
3001672 Alzheimer's Specimen 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AD
  • dementia
  • familial Alzheimer's disease (FAD)
  • presenile dementia
Early-Onset Alzheimer's Panel, Sequencing