Ordering Recommendation

Diagnostic and presymptomatic testing for individuals with a clinical suspicion for or a family history of Alzheimer’s disease diagnosed before age 65.

Mnemonic
ALZ NGS
Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (K2 or K3EDTA) or Yellow (ACD Solution A or B). Peripheral blood required.

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.  

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note

Genes tested: APP, PSEN1, PSEN2

Hotline History
N/A
CPT Codes

81405; 81406

Components
Component Test Code* Component Chart Name LOINC
3001586 Alzheimer's Interp 35474-6
3001672 Alzheimer's Specimen 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AD
  • dementia
  • familial Alzheimer's disease (FAD)
  • presenile dementia
Early-Onset Alzheimer's Panel, Sequencing