Ordering Recommendation

Diagnostic and presymptomatic testing for individuals with a clinical suspicion for or a family history of Alzheimer’s disease diagnosed before age 65.

Mnemonic
ALZ NGS
Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (K2 or K3EDTA) or Yellow (ACD Solution A or B). Peripheral blood required.

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.  

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: APP, PSEN1, PSEN2

Hotline History
N/A
CPT Codes

81405; 81406

Components
Component Test Code* Component Chart Name LOINC
3001586 Alzheimer's Interp 35474-6
3001672 Alzheimer's Specimen 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AD
  • dementia
  • familial Alzheimer's disease (FAD)
  • presenile dementia
Early-Onset Alzheimer's Panel, Sequencing