Ordering Recommendation

Evaluate patients suspected of having hypersensitivity pneumonitis induced by exposure to Aspergillus flavus, Aspergillus fumigatus, Aurebasidium pullulans, Micropolyspora faeni, Saccharomonospora viridis, Thermoactinomyces candidus, Thermoactinomyces vulgaris, or pigeon serum.

Mnemonic
HYPEREXT
Methodology

Qualitative Immunodiffusion/Quantitative ImmunoCAP Fluorescent Enzyme Immunoassay

Performed

Sun-Sat

Reported

3-7 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer two 2.5 mL aliquots of serum to individual ARUP Standard Transport Tubes. (Min: 1 mL Per aliquot)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Interpretive Data

Allergen results of 0.10-0.34 kU/L are intended for specialist use as the clinical relevance is undetermined. Even though increasing ranges are reflective of increasing concentrations of allergen-specific IgE, these concentrations may not correlate with the degree of clinical response or skin testing results when challenged with a specific allergen. The correlation of allergy laboratory results with clinical history and in vivo reactivity to specific allergens is essential. A negative test may not rule out clinical allergy or even anaphylaxis.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Note

Testing includes antibodies directed at Aspergillus fumigatus #1, A. fumigatus #2, A. fumigatus #3, A. fumigatus #6, A. flavus, Aureobasidium pullulans, Micropolyspora faeni, Thermoactinomyces vulgaris #1, T. candidus, Saccharomonospora viridis and pigeon serum. Testing also includes the following allergens: Feather Mix, Beef, Pork, and Phoma betae.

Hotline History
N/A
CPT Codes

86003 x3; 86005; 86331 x6; 86606 x5

Components
Component Test Code* Component Chart Name LOINC
0055037 Allergen, Animal, Feather Mix IgE 31161-3
0055041 Allergen, Interp, Immunocap Score IgE 33536-4
0055066 A. fumigatus #1 Ab, Precipitin 6808-0
0055067 A. fumigatus #6 Ab, Precipitin 6809-8
0055068 A. pullulans Ab, Precipitin 6810-6
0055069 Pigeon Serum Ab, Precipitin 6733-0
0055071 M. faeni Ab, Precipitin 6818-9
0055072 T. vulgaris #1 Ab, Precipitin 35317-7
0055096 Allergen, Food, Beef IgE 6039-2
0055220 A. flavus Ab, Precipitin 23820-4
0055221 A. fumigatus #2 Ab, Precipitin 30036-8
0055222 A. fumigatus #3 Ab, Precipitin 15151-4
0055223 S. viridis Ab, Precipitin 15209-0
0055224 T. candidus Ab, Precipitin 21560-8
0055390 Allergen, Fungi/Mold, Phoma betae IgE 6216-6
0099780 Allergen, Food, Pork IgE 6219-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Farmer's Lung Panel
  • HP
  • Hyper Pneumo
  • hypersensitivity pneumonitis
Hypersensitivity Pneumonitis Extended Panel (Farmer's Lung Panel)