Ordering Recommendation
Genotype test to assess risk, due to genetics, for severe myelosuppression with standard dosing of thiopurine drugs. Use for individuals being considered for thiopurine therapy or who have had an adverse reaction to thiopurine therapy. Preferred test for patients with recent heterologous blood transfusion. Can be performed irrespective of thiopurine therapy.
Mnemonic
Methodology
Polymerase Chain Reaction/Fluorescence Monitoring
Performed
Varies
Reported
5-10 days
New York DOH Approval Status
Specimen Required
Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B).
Transport 3 mL whole blood. (Min: 1 mL)
Refrigerated.
Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month
Reference Interval
By report
Interpretive Data
Refer to report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
Whole blood is the preferred specimen. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting.
Hotline History
Hotline History
CPT Codes
81335; 81306
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3001536 | TPMT2 Specimen | 31208-2 |
3001537 | TPMT Genotype | 41048-0 |
3001538 | NUDT15 Genotype | 93194-9 |
3001539 | TPMT2 Interpretation | 50398-7 |
Aliases
- 6-mercaptopurine
- 6-MP
- 6-TG
- 6-thioguanine
- AZA toxicity
- Azathioprine
- nucleoside diphosphate linked moiety X
- nudix
- NUDT15 mutation
- S-adenosyl-L-methionine genotype
- Thioguanine
- Thiopurine
- Thiopurine S-methyltransferase genotype
- TPMT genetics
- TPMT mutation