3001513
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CYP2D6

2D6GENO
Example Reports
Intermediate
Normal
Poor
Ultra Rapid

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Additional Technical Information

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Informed Consent for Genetic Testing (Required for NY patients)

Ordering Recommendation

Assesses genetic risk of abnormal drug metabolism for CYP2D6 substrates. May aid in drug selection and dose planning for drugs metabolized by CYP2D6.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring/Sequencing

Performed

Varies

Reported

5-10 days
If reflexed: 5-7 additional days are required for LR-PCR and sequencing

Reference Interval

By report

Interpretive Data

Refer to report.

Counseling and informed consent are recommended for genetic testing. Consent forms are avialable online.

Compliance Category

Laboratory Developed Test (LDT)

Note

If long-range PCR/duplication testing is performed, additional charges will apply. Approximately less than 5% of samples require 2D6 copy number determination.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/13/2023
X
N/A

CPT Codes

81226; if reflexed, add 81479

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Components

Component Test Code* Component Chart Name LOINC
2008926 CYP2D6 Phenotype 79715-9
3001514 2D6GENO Specimen 31208-2
3001515 CYP2D6 Genotype 40425-1
3001516 2D6GENO Interpretation 50398-7
3016898 EER CYP2D6 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • antidepressants
  • tramadol
  • venlafaxine
  • haloperidol
  • desipramine
  • antipsychotics
  • paroxetine
  • SSRIs
  • ondansetron
  • codeine
  • tropisetron
  • aripiprazole
  • clomipramine
  • doxepine
  • risperidone
  • mitrazapine
  • 2D6
  • hydrocodone
  • opioids
  • amitriptyline
  • TCAs
  • CYP2D6
  • Cytochrome P450 2D6
  • atomoxetine
  • propafenone
  • fluvoxamine
  • oxycodone
  • tamoxifen
  • zuclopenthixol
  • metoprolol
  • imipramine
  • nortriptyline
  • trimipramine
  • flecainide
CYP2D6