Ordering Recommendation

Assesses genetic risk of abnormal drug metabolism for CYP2D6 substrates. May aid in drug selection and dose planning for drugs metabolized by CYP2D6.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature


Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month


Polymerase Chain Reaction (PCR)/Fluorescence Monitoring/Sequencing




5-10 days
If reflexed: 5-7 additional days are required for LR-PCR and sequencing

Reference Interval

By report

Interpretive Data

Refer to report.

Counseling and informed consent are recommended for genetic testing. Consent forms are avialable online.

Compliance Category

Laboratory Developed Test (LDT)


Whole blood is the preferred specimen type. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting. Saliva is only validated for the OpenArray and CNV portions of testing and not the long-range PCR/duplication testing. Long-range PCR/duplication testing will not be performed for saliva samples.

If long-range PCR/duplication testing is performed, additional charges will apply. Approximately less than 5% of samples require 2D6 copy number determination.

Hotline History


CPT Codes

81226; if reflexed, add 81479


Component Test Code* Component Chart Name LOINC
2008926 CYP2D6 Phenotype 79715-9
3001514 2D6GENO Specimen 31208-2
3001515 CYP2D6 Genotype 40425-1
3001516 2D6GENO Interpretation 50398-7
3016898 EER CYP2D6 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • 2D6
  • amitriptyline
  • antidepressants
  • antipsychotics
  • aripiprazole
  • atomoxetine
  • clomipramine
  • codeine
  • CYP2D6
  • Cytochrome P450 2D6
  • desipramine
  • doxepine
  • flecainide
  • fluvoxamine
  • haloperidol
  • hydrocodone
  • imipramine
  • metoprolol
  • mitrazapine
  • nortriptyline
  • ondansetron
  • opioids
  • oxycodone
  • paroxetine
  • propafenone
  • risperidone
  • SSRIs
  • tamoxifen
  • TCAs
  • tramadol
  • trimipramine
  • tropisetron
  • venlafaxine
  • zuclopenthixol