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CYP2D6
Ordering Recommendation
Assesses genetic risk of abnormal drug metabolism for CYP2D6 substrates. May aid in drug selection and dose planning for drugs metabolized by CYP2D6.
New York DOH Approval Status
Specimen Required
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).
Transport 3 mL whole blood. (Min: 1 mL)
Preferred transport temp: Refrigerated
Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.
Counseling and informed consent are recommended for genetic testing. Consent forms are linked above.
New York Clients: Informed consent is required with submission.
Room temperature: 3 days; Refrigerated: 1 week; Frozen: 1 month
Methodology
Polymerase Chain Reaction (PCR) / Fluorescence Monitoring / Sequencing
Performed
Varies
Reported
5-10 days
If reflexed: 5-7 additional days are required for LR-PCR and sequencing
Reference Interval
Refer to report
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
If long-range PCR/duplication testing is performed, additional charges will apply. Approximately less than 5% of samples require 2D6 copy number determination.
Hotline History
CPT Codes
81226; if reflexed, add 81479
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2008926 | CYP2D6 Phenotype | 79715-9 |
| 3001514 | 2D6GENO Specimen | 31208-2 |
| 3001515 | CYP2D6 Genotype | 40425-1 |
| 3001516 | 2D6GENO Interpretation | 50398-7 |
| 3016898 | EER CYP2D6 | 11526-1 |
Aliases
- 2D6
- amitriptyline
- antidepressants
- antipsychotics
- aripiprazole
- atomoxetine
- clomipramine
- codeine
- CYP2D6
- Cytochrome P450 2D6
- desipramine
- doxepine
- flecainide
- fluvoxamine
- haloperidol
- hydrocodone
- imipramine
- metoprolol
- mitrazapine
- nortriptyline
- ondansetron
- opioids
- oxycodone
- paroxetine
- propafenone
- risperidone
- SSRIs
- tamoxifen
- TCAs
- tramadol
- trimipramine
- tropisetron
- venlafaxine
- zuclopenthixol
