Ordering Recommendation

Assesses genetic risk of abnormal drug metabolism for CYP2C19 substrates. May aid in drug selection and dose planning for drugs metabolized by CYP2C19.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature


Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month


Polymerase Chain Reaction (PCR)/Fluorescence Monitoring




5-10 days

Reference Interval

By report

Interpretive Data

Refer to report

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Couseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


Whole blood is the preferred specimen. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
2008936 CYP2C19 Phenotype 79714-2
3001509 2C19GENO Specimen 31208-2
3001510 CYP2C19 Genotype 57132-3
3001511 2C19GENO Interpretation 50398-7
3016869 EER CYP2C19 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • 2C19
  • amitriptyline
  • antidepressants
  • clomipramine
  • clopidogrel
  • CYP2C19
  • Cytochrome P450 2C19 Genotype
  • dexlansoprazole
  • doxepine
  • escitalopram
  • imipramine
  • lansoprazole
  • omeprazole
  • pantoprazole
  • Plavix
  • PPIs
  • protein pump inhibitors
  • rabeprazole
  • sertraline
  • SSRI
  • TCA
  • trimipramine
  • voriconazole