Aid in the diagnosis of aggressive large B-cell lymphoma with intermediate features between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL) and confirmation of suspected double-hit lymphoma.
Fluorescence in situ Hybridization (FISH)
3-7 days, if reflexed, add 3 days for each reflex
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 8 unstained 3-micron slides. (Min: 4 slides) Protect paraffin block from excessive heat. Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.
Include surgical pathology report.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
Analyte Specific Reagent (ASR)
If Aggressive B-Cell Lymphoma Reflex Panel by FISH is positive, then IGH-BCL2 Fusion, t(14;18) by FISH (ARUP test code 3001298) will be added. If IGH-BCL2 Fusion, t(14;18) by FISH is negative, then BCL6 (3q27) Gene Rearrangement by FISH (ARUP test code 3001311) will be added. Additional charges apply.
88366, if reflexed add 88366; if further reflexed add 88366
|Component Test Code*||Component Chart Name||LOINC|
|3000616||MYC FISH Reference Number|
|3000617||MYC FISH Source|
|3000618||MYC FISH Result|
|3000702||Total Cell Count||78236-7|
- 8q24 gene rearrangement FISH
- Burkitt's Lymphoma; DLBCL
- Double hit lymphoma, BCL6 FISH, BCL2 FISH
- LSI MYC FISH
- MYC FISH
- MYC gene rearrangement FISH