Aid in the diagnosis of aggressive large B-cell lymphoma with intermediate features between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL) and confirmation of suspected double-hit lymphoma.
Fluorescence in situ Hybridization (FISH)
3-7 days, if reflexed, add 3 days for each reflex
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 8 unstained 3-micron slides. (Min: 4 slides) Protect paraffin block from excessive heat. Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Analyte Specific Reagent (ASR)
If Aggressive B-Cell Lymphoma Reflex Panel by FISH is positive, then IGH-BCL2 Fusion, t(14;18) by FISH (ARUP test code 3001298) will be added. If IGH-BCL2 Fusion, t(14;18) by FISH is negative, then BCL6 (3q27) Gene Rearrangement by FISH (ARUP test code 3001311) will be added. Additional charges apply.
88366, if reflexed add 88366; if further reflexed add 88366
|Component Test Code*||Component Chart Name||LOINC|
|3000616||MYC FISH Reference Number|
|3000617||MYC FISH Source|
|3000618||MYC FISH Result|
|3000702||Total Cell Count||78236-7|
- 8q24 gene rearrangement FISH
- Burkitt's Lymphoma; DLBCL
- Double hit lymphoma, BCL6 FISH, BCL2 FISH
- LSI MYC FISH
- MYC FISH
- MYC gene rearrangement FISH