Ordering Recommendation
Differential evaluation of encephalitis of unknown origin with subacute onset of seizures, confusion, memory loss, and/or behavioral change. Detects antibodies in addition to those included in Autoimmune Encephalitis Reflexive Panel, Serum (2013601). Testing for LGI1 and CASPR2 antibodies is always performed rather than only as a reflex. For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended; refer to Paraneoplastic Reflexive Panel (3002929).
Mnemonic
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer three (3) 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Frozen.
Contaminated specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 30 days (avoid repeated freeze/thaw cycles)
Reference Interval
Test Number |
Components |
Reference Interval |
||||||
---|---|---|---|---|---|---|---|---|
2004221 | N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer | Less than 1:10 | ||||||
2001771 | Glutamic Acid Decarboxylase Antibody | 0.0-5.0 IU/mL | ||||||
2004890 | Voltage-Gated Potassium Channel (VGKC) Antibody, Serum |
|
||||||
2013320 | Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | ||||||
2009456 | Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, Serum | Less than 1:10 | ||||||
2009452 | Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, Serum | Less than 1:10 | ||||||
3001260 | Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | ||||||
3001270 | Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | ||||||
3001277 | Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | ||||||
3004359 | Dipeptidyl Aminopeptidase-Like Protein 6 (DPPX) Antibody, IgG by IFA With Reflex to Titer, Serum | Effective November 15, 2021 Less than 1:10 |
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
If N-methyl-D-Aspartate Receptor Antibody is positive, then a titer will be added. Additional charges apply.
If Aquaporin-4 Receptor antibody IgG is positive, then a titer will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If AMPAR Antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABABR Antibody IgG is positive, then a titer will be added. Additional charges apply.
If MOG Antibody IgG is positive, then a titer will be added. Additional charges apply.
If DPPX Antibody IgG is positive, then a titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
83519; 86052; 86341; 86362; 86255 x6; if reflexed, add 86256 x8
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2001772 | Glutamic Acid Decarboxylase Antibody | 56540-8 |
2004222 | N-methyl-D-Aspartate Receptor Ab, Serum | 80221-5 |
2004890 | Voltage-Gated Potassium Channel Ab, Ser | 41871-5 |
2009453 | CASPR2 Ab IgG Screen by IFA, Serum | 82979-6 |
2009457 | LGI1 Ab IgG Screen by IFA, Serum | 82978-8 |
2013322 | Neuromyelitis Optica/AQP4-IgG, Serum | 63439-4 |
3001261 | AMPA Receptor Ab IgG Screen, Serum | 82733-7 |
3001271 | GABA-B Receptor Ab IgG Screen, Serum | 93428-1 |
3001278 | MOG Antibody IgG Screen, Serum | 91545-4 |
3004361 | DPPX Ab IgG CBA IFA Screen, Serum | 94676-4 |