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RET Gene Rearrangements by FISH
Ordering Recommendation
Use to detect RET gene rearrangements in solid tumors. Does not identify the translocation partner or variant.
New York DOH Approval Status
Specimen Required
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tumor tissue. Transport tissue block or 4 unstained, consecutively cut, 5-micron thick sections, mounted on positively charged glass slides. (Min: 2 slides) Protect paraffin block and/or slides from excessive heat.
Room temperature. Also acceptable: Refrigerated.
Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
Performed
Varies
Reported
3-7 days
Reference Interval
By report
Interpretive Data
Refer to report.
Analyte Specific Reagent (ASR)
Note
Hotline History
CPT Codes
88366
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3000685 | RET FISH Reference Number | |
| 3000686 | RET FISH Source | |
| 3000687 | RET FISH Result | |
| 3000703 | Scoring Method | 81304-8 |
| 3002950 | Total Cell Count | 78236-7 |
