Ordering Recommendation

Diagnose oligodendroglioma brain tumors; indicated in both low-grade and high-grade (anaplastic) oligodendrogliomas.

Mnemonic
1P19Q_FISH
Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Monday-Friday

Reported

3-7 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect paraffin block from excessive heat. Transport block or 6 unstained (4 micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min 3 slides)

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Analyte Specific Reagent (ASR)

Note
Hotline History
N/A
CPT Codes

88377 x2

Components
Component Test Code* Component Chart Name LOINC
3000665 1p19q FISH Reference Number
3000666 1p19q FISH Source
3000667 1p/1q Ratio
3000668 1p Result
3000669 Chromosome 1 Polysomy
3000670 19q Result 42634-6
3000671 19q/19p Ratio
3000672 Chromosome 19 Polysomy
3000703 Scoring Method 81304-8
3002933 1P Total Cell Count 78236-7
3002934 19Q Total Cell Count 78236-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 1p deletion FISH
  • 1p,1q codeletion FISH
  • 1p/19q Deletion
  • 1p/19q Deletion in Gliomas, FISH, Tissue
  • 1p/19q deletion in Oligodendroglioma
  • 1p/19q FISH; 1p/19q in oligodendrogliomas; 1q deletion FISH
  • Chromosome Analysis by FISH for 1p/19q Deletion in Gliomas
  • FISH for 1p/19q Deletion in Gliomas
  • LOH (Loss of Heterozygosity) 1p/19q in Gliomas
  • Loss of Heterozygosity (LOH) 1p/19q in Gliomas
1p/19q Deletion by FISH