3001309
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1p/19q Deletion by FISH

1P19Q_FISH
Example Reports
Negative
Positive

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Additional Technical Information

Ordering Recommendation

Diagnose oligodendroglioma brain tumors; indicated in both low-grade and high-grade (anaplastic) oligodendrogliomas.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect paraffin block from excessive heat. Transport block or 6 unstained (4 micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min 3 slides)

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Mon-Fri

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)

Note

Hotline History

N/A

CPT Codes

88377 x2

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Components

Component Test Code* Component Chart Name LOINC
3000665 1p19q FISH Reference Number
3000666 1p19q FISH Source
3000667 1p/1q Ratio
3000668 1p Result
3000669 Chromosome 1 Polysomy
3000670 19q Result 42634-6
3000671 19q/19p Ratio
3000672 Chromosome 19 Polysomy
3000703 Scoring Method 81304-8
3002933 1P Total Cell Count 78236-7
3002934 19Q Total Cell Count 78236-7
3003802 1P Percent Deleted
3003803 19Q Percent Deleted
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 1p deletion FISH
  • 1p,1q codeletion FISH
  • 1p/19q Deletion
  • 1p/19q Deletion in Gliomas, FISH, Tissue
  • 1p/19q deletion in Oligodendroglioma
  • 1p/19q FISH; 1p/19q in oligodendrogliomas; 1q deletion FISH
  • Chromosome Analysis by FISH for 1p/19q Deletion in Gliomas
  • FISH for 1p/19q Deletion in Gliomas
  • LOH (Loss of Heterozygosity) 1p/19q in Gliomas
  • Loss of Heterozygosity (LOH) 1p/19q in Gliomas
1p/19q Deletion by FISH