Detect ROS1 gene rearrangements in solid tumors. Does not identify the translocation partner or variant.
Fluorescence in situ Hybridization (FISH)
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (4- micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808), available online through eSupply using ARUP Connector contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min: 2 slides)
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.
Include surgical pathology report.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|3000654||ROS1 FISH Reference Number|
|3000655||ROS1 FISH Source|
|3000656||ROS1 FISH Result||59050-5|
|3002951||Total Cell Count||78236-7|