Screening test for all ALK fusions. Use if the companion diagnostic test for crizotinib is required. Does not identify the translocation partner or variant.
Fluorescence in situ Hybridization (FISH)
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tumor tissue. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 4 unstained, consecutively cut, 4-micron thick sections, mounted on positively charged glass slides in a tissue transport kit (ARUP supply #47808 recommended but not required) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides)
Room temperature. Also acceptable: Refrigerated.
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.
Include surgical pathology report with reason for referral. The laboratory will not reject specimens that arrive without a pathology report but will hold the specimen until this information is received.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Analyte Specific Reagent (ASR)
|Component Test Code*||Component Chart Name||LOINC|
|3000627||ALK FISH Reference Number|
|3000628||ALK FISH Source||31208-2|
|3000629||ALK FISH Result||78205-2|
|3002935||Total Cell Count||78236-7|