Ordering Recommendation

Aid in the differential diagnosis between well-differentiated liposarcoma and benign lipoma in individuals diagnosed with or suspected of having well-differentiated liposarcoma based on tissue morphology.

Mnemonic
MDM2_FISH
Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Monday-Friday

Reported

3-7 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Protect paraffin block from excessive heat. Transport block or 5 unstained (4-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min 2 slides)

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Analyte Specific Reagent (ASR)

Note
Hotline History
N/A
CPT Codes

88377

Components
Component Test Code* Component Chart Name LOINC
3000620 MDM2 FISH Reference Number
3000621 MDM2 FISH Source
3000622 MDM2/CEP12 FISH Ratio
3000623 Average MDM2 Signal Number per Cell
3000624 Average CEP12 Signal Number per Cell
3000625 MDM2 FISH Result
3000703 Scoring Method 81304-8
3002946 Total Cell Count 78236-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • MDM2 FISH
  • MDM2 Gene amplification
MDM2 Gene Amplification by FISH