Aid in the differential diagnosis between well-differentiated liposarcoma and benign lipoma in individuals diagnosed with or suspected of having well-differentiated liposarcoma based on tissue morphology.
Fluorescence in situ Hybridization (FISH)
New York DOH Approval Status
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Protect paraffin block from excessive heat. Transport block or 5 unstained (4-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min 2 slides)
Room temperature or refrigerated. Ship in cooled container during summer months.
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Analyte Specific Reagent (ASR)
|Component Test Code*||Component Chart Name||LOINC|
|3000620||MDM2 FISH Reference Number|
|3000621||MDM2 FISH Source|
|3000622||MDM2/CEP12 FISH Ratio|
|3000623||Average MDM2 Signal Number per Cell|
|3000624||Average CEP12 Signal Number per Cell|
|3000625||MDM2 FISH Result|
|3002946||Total Cell Count||78236-7|
- MDM2 FISH
- MDM2 Gene amplification