Ordering Recommendation

Facilitates diagnosis of Burkitt lymphoma (BL) and B-cell lymphoma with features intermediate between BL and diffuse large B-cell lymphoma (DLBCL).

Mnemonic
IGHMC FISH
Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Monday-Friday

Reported

3-7 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3-micron thick sections) positively charge slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect ™ or contact ARUP Client Services at (800) 522-2787 (kit is recommended but not necessary). (Min: 2 slides)  If sending precut slides, do not oven bake.

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Note
Hotline History
N/A
CPT Codes

88366

Components
Component Test Code* Component Chart Name LOINC
3000612 IGH-MYC FISH Reference Number
3000613 IGH-MYC FISH Source
3000614 IGH-MYC FISH Result
3000702 Total Cell Count 78236-7
3000703 Scoring Method 81304-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • C-MYC by FISH; IGH-MYC Fusion FISH
  • IGH-MYC Fusion FISH
  • IGH-MYC rearrangement FISH
  • MYC, Fluorescent In Situ Hybridization (FISH)
  • Translocations 8 and 14 by FISH
IGH-MYC Fusion t(8;14) by FISH