Ordering Recommendation

Use in the initial evaluation of inflammatory central nervous system (CNS) demyelinating diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed, contaminated, or severely lipemic specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)


Semi-Quantitative Cell-Based Indirect Fluorescent Antibody


Mon, Wed, Fri


1-6 days

Reference Interval

Test Number
Reference Interval
  NMO/AQP4 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  MOG Ab IgG CBA-IFA Screen, Serum Less than 1:10

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


If Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then an Aquaporin-4 Receptor Antibody, IgG by IFA, Serum Titer will be added.  If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG will be added. Additional charges apply.

Hotline History


CPT Codes

86362; 86052; if reflexed, add 86256 x2


Component Test Code* Component Chart Name LOINC
2013322 NMO/AQP4 Ab IgG CBA-IFA Screen, Serum 63439-4
3001278 MOG Ab IgG CBA-IFA Screen, Serum 91545-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Acute disseminated encephalomyelitis
  • AQP
  • AQP4
  • AQP4 antibody
  • Aquaporin
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • Devic's Ab
  • Devic's Antibody
  • MOG
  • MOG antibody
  • MOG IgG
  • Myelin oligodendrocyte glycoprotein
  • Myelopathy
  • Neuromyelitis optica
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • Neuromyelitis optica spectrum disorder
  • NMO
  • NMO-IgG
  • Optic neuritis
  • Optic Neuritis Ab
  • Optic Neuritis Antibody
  • Optic-Spinal MS Antibody
  • Pediatric CNS disorders
  • Transverse myelitis
Autoimmune CNS Demyelinating Disease Reflexive Panel