3001283
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Autoimmune CNS Demyelinating Disease Reflexive Panel

CNS PAN
Example Reports
Detected
None Detected

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Additional Technical Information

Ordering Recommendation

Use in the initial evaluation of inflammatory central nervous system (CNS) demyelinating diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Transfer 4 mL to ARUP standard transport tube. (Min: 3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed, contaminated, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody

Performed

Mon, Wed, Fri

Reported

1-6 days

Reference Interval

Test Number
 Components
 Reference Interval
  NMO/AQP4 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  MOG Ab IgG CBA-IFA Screen, Serum Less than 1:10

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

If Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then an Aquaporin-4 Receptor Antibody, IgG by IFA, Serum Titer will be added. If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
04/20/2026
X
N/A

CPT Codes

86362; 86052; if reflexed, add 86256 x2

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Components

Component Test Code* Component Chart Name LOINC
2013322 NMO/AQP4 Ab IgG CBA-IFA Screen, Serum 63439-4
3001278 MOG Ab IgG CBA-IFA Screen, Serum 91545-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Acute disseminated encephalomyelitis
  • AQP
  • AQP4
  • AQP4 antibody
  • Aquaporin
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • Devic's Ab
  • Devic's Antibody
  • MOG
  • MOG antibody
  • MOG IgG
  • Myelin oligodendrocyte glycoprotein
  • Myelopathy
  • Neuromyelitis optica
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • Neuromyelitis optica spectrum disorder
  • NMO
  • NMO-IgG
  • NMOSD
  • Optic neuritis
  • Optic Neuritis Ab
  • Optic Neuritis Antibody
  • Optic-Spinal MS Antibody
  • Pediatric CNS disorders
  • Transverse myelitis
Autoimmune CNS Demyelinating Disease Reflexive Panel