Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Aid in diagnosis of limbic encephalitis. May be used in monitoring treatment response in individuals who are antibody positive. The presence of GABA-BR antibodies may be associated with seizures; GABA-BR encephalitis may be paraneoplastic as about 50% of cases are associated with small cell lung cancer.
New York DOH Approval Status
Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.15 mL)
Hemolyzed, contaminated, or severely lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody
Less than 1:1
Gamma-amino butyric acid receptor, type B (GABA-BR) antibody is found in a subset of patients with autoimmune epilepsy and other autoimmune neurologic phenotypes; it may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response. A negative test result does not rule out a diagnosis of autoimmune neurologic disease. Results should be interpreted in correlation with the patients clinical history and other laboratory findings.
This indirect fluorescent antibody assay utilizes GABA-BR transfected cell lines for the detection and semiquantification of GABA-BR IgG antibody.
Laboratory Developed Test (LDT)
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, CSF is performed. Additional charges apply.
86255; if reflexed, add 86256
|Component Test Code*||Component Chart Name||LOINC|
|3001268||GABA-BR Ab IgG CBA-IFA Screen, CSF||82984-6|
- GABA Receptor
- GABA Reflex
- GABA Titer