Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by CBA-IFA with Reflex to Titer, CSF
Ordering Recommendation
Aid in diagnosis of limbic encephalitis. May be used in monitoring treatment response in individuals who are antibody positive. The presence of GABA-BR antibodies may be associated with seizures; GABA-BR encephalitis may be paraneoplastic as about 50% of cases are associated with small cell lung cancer.
Mnemonic
Methodology
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody
Performed
Wed
Reported
1-8 days
New York DOH Approval Status
Specimen Required
CSF.
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL)
Refrigerated.
Hemolyzed, contaminated, or severely lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
Less than 1:1
Interpretive Data
Gamma-amino butyric acid receptor, type B (GABA-BR) antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune encephalitis.
This indirect fluorescent antibody assay utilizes GABA-BR transfected cell lines for the detection and semi-quantification of GABA-BR IgG antibody.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, CSF is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, CSF is performed. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86255; if reflexed, add 86256
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3001268 | GABA-B Receptor Ab IgG Screen, CSF | 82984-6 |
Aliases
- GABA
- GABA Receptor
- GABA Reflex
- GABA Titer
- GABA-B