Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Aid in diagnosis of limbic encephalitis. May be used in monitoring treatment response in individuals who are antibody positive. The presence of AMPA receptor antibodies may be associated with psychosis, with or without seizures; AMPA encephalitis may be paraneoplastic but tumor type is variable (thymic, lung, and breast cancer).
MnemonicUnique test identifier.
AMPA CSF
MethodologyProcess(es) used to perform the test.
Semi-Quantitative Indirect Fluorescent Antibody
PerformedDays of the week the test is performed.
Wed
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-8 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
CSF.
Specimen Preparation
Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Hemolyzed, contaminated, or severely lipemic specimens.
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Less than 1:1
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune encephalitis.
This indirect fluorescent antibody assay utilizes AMPA transfected cell lines for detection and semi-quantification of AMPA IgG antibody.
Compliance Category
Laboratory Developed Test (LDT)
NoteAdditional information related to the test.
If Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF IgG is positive, then an Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody Titer, IgG, CSF is reported. Additional charges apply.
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
AMPA
AMPA Receptor Ab
AMPA Reflex
AMPA Titer
Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, CSF
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