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Prion Markers (CJD), CSF
Ordering Recommendation
May aid in the diagnosis of Creutzfeldt-Jakob disease (CJD). This test uses qualitative real-time quaking-induced conversion to identify the causative agent of CJD, and also includes indirect markers of neurodegenerative disease.
New York DOH Approval Status
Specimen Required
Patient must be 12 years of age or older.
CSF
The first 2 mL of CSF that flows from the tap should be discarded. Transfer 2 mL CSF to ARUP standard transport tubes or other polypropylene tubes, taking care to avoid blood contamination from the tap. Freeze at -20 within 20 minutes of collection. (Min: 1 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.
CRITICAL FROZEN
Completed requisition form required. Cloudy or pink specimens may result in partial results for some components.
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: Indefinitely
Methodology
Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) / Qualitative Real-Time Quaking-Induced Conversion
Performed
Varies
Reported
12-22 days
Reference Interval
By report
Interpretive Data
Performed by non-ARUP Laboratory
Note
Repeat testing should be collected no sooner than 2 weeks following last encounter.
Hotline History
Hotline History
CPT Codes
86317; 0035U
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3001256 | Prion Markers (CJD), CSF | 97502-9 |
Aliases
- 14-3-3 Protein Tau, Total, CSF
- Human Prion Disease
- RT QuIC
- Creutzfeldt-Jakob Disease
NPDPSC
