Ordering Recommendation

May aid in the diagnosis of Creutzfeldt-Jakob disease after other neurodegenerative conditions have been ruled out.

Mnemonic
14-3-3 TAU
Methodology

Qualitative Western Blot/Quantitative Enzyme-Linked Immunosorbent Assay/Qualitative Real-Time Quaking-Induced Conversion

Performed

Varies

Reported

7-17 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Patient must be 12 years of age or older.

Collect

CSF.

Specimen Preparation

The first 2 mL of CSF that flows from the tap should be discarded. Transfer 5 mL CSF to ARUP Standard Transport Tubes and freeze immediately. (Min: 2 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions
Remarks

Completed requisition form required.

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: Indefinitely (One freeze/thaw cycle is acceptable.)

Reference Interval

By report

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Repeat testing should be collected no sooner than 2 weeks following last encounter.

Hotline History
N/A
CPT Codes

86317; 84182; 0035U

Components
Component Test Code* Component Chart Name LOINC
3001256 14-3-3 Protein Tau, Total, CSF 19146-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CJD
  • Creutzfeldt-Jakob Disease
  • Human Prion Disease
  • RT QuIC
14-3-3 Protein Tau, Total, CSF

NPDPSC