Ordering Recommendation

Intended for use in patients with viral loads ≥1,000 copies/mL. HIV-1 phenotyping test to determine the tropism (ie, CCR5 or CXCR4) of the virus in patients being considered for CCR5 antagonist therapy.

Mnemonic

HIV TROFIL

Methodology

Polymerase Chain Reaction (PCR)/Culture

Performed

Varies

Reported

27-38 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (K2EDTA) or Plasma Preparation Tube (PPT).

Specimen Preparation

Separate from cells within 6 hours of collection. Transfer 3 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 3 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Thawed specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 2 weeks

Reference Interval

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Procedure should be used for patients with documented HIV-1 infection and viral loads greater than 1000 copies/mL.

Hotline History

N/A

CPT Codes

87999

Components

Component Test Code* Component Chart Name LOINC
3001247 EER Trofile Coreceptor Tropism 51969-4
3001248 Trofile Coreceptor Tropism 57182-8
3001249 Trofile Coreceptor Tropism, Tropotype 51969-4
3001250 Trofile Coreceptor Tropism, Interp 77202-0
3001251 Trofile Coreceptor Tropism, Methodology 49549-9
3001252 Trofile Coreceptor Tropism, References 75608-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CCR5
  • Chemokine Coreceptor Tropism Trofile
  • CXCR4
Human Immunodeficiency Virus Type 1 (HIV-1) Trofile Co-Receptor Tropism

Monogram Biosciences