Ordering Recommendation

Intended for use in patients with viral loads ≥2,000 copies/mL. Recommended testing for patients with HCV genotype 1 prior to initiating simeprevir therapy. Identifies the Q80K polymorphism.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lavender (EDTA) or Plasma Preparation Tube (PPT).

Specimen Preparation

Separate from cells within 6 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Thawed specimens.


Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 2 weeks


Polymerase Chain Reaction/Sequencing




10-17 days

Reference Interval

By report

Interpretive Data

Compliance Category

Performed by non-ARUP Laboratory


Procedure should be used for patients with HCV genotype (subtype) 1a or 1b and a viral load greater than 2000 IU/mL.

Hotline History


CPT Codes

87900; 87902


Component Test Code* Component Chart Name LOINC
3001235 EER HCV GenoSure NS3 and NS4A 32286-7
3001236 HCV GenoSure NS3 and NS4A 32286-7
3001237 HCV GenoSure NS3 and NS4A Interpretation 77202-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • HCV Drug Resistance
  • NS3/4 Resistance Analysis
  • Q80K Polymorphism
Hepatitis C Virus (HCV) GenoSure NS3 and NS4A

Monogram Biosciences