Ordering Recommendation

Recommended testing for HCV genotype 1 patients prior to initiating simeprevir therapy. Identifies the Q80K polymorphism.

Mnemonic
HCV NS3/4A
Methodology

Polymerase Chain Reaction/Sequencing

Performed

Varies

Reported

10-17 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or Plasma Preparation Tube (PPT).

Specimen Preparation

Separate from cells within 6 hours of collection. Transfer 3 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 3 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Thawed specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 2 weeks

Reference Interval

By report

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Procedure should be used for patients with HCV genotype (subtype) 1a or 1b and a viral load greater than 2000 IU/mL.

Hotline History
N/A
CPT Codes

87900; 87902

Components
Component Test Code* Component Chart Name LOINC
3001235 EER HCV GenoSure NS3 and NS4A 32286-7
3001236 HCV GenoSure NS3 and NS4A 32286-7
3001237 HCV GenoSure NS3 and NS4A Interpretation 77202-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HCV Drug Resistance
  • NS3/4 Resistance Analysis
  • Q80K Polymorphism
Hepatitis C Virus (HCV) GenoSure NS3 and NS4A

Monogram Biosciences