Optimal test to evaluate individuals with hereditary hemolytic anemia or unexplained long-standing hemolytic anemia. A faculty hematopathologist personally directs and interprets each stage of testing to completion. A comprehensive report is provided. Do not use for the follow-up of an individual with a known diagnosis.
High Performance Liquid Chromatography (HPLC)/Electrophoresis/RBC Solubility/Polymerase Chain Reaction (PCR)/Fluorescence Resonance Energy Transfer/Sequencing, Spectrophotometry, Visual Identification, Quantitative Enzymatic, Quantitative Flow Cytometry, Cytochemical Stain, Multiplex Ligation-Dependent Probe Amplification
3 whole blood Lavender (K2EDTA) or Pink (K2EDTA) specimens and 3-5 peripheral blood smears.
Transfer specimens using ARUP kit (ARUP supply # 54388) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.
Submit with Order: Patient history form, including information from a recent CBC, is required for interpretation.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable
Laboratory Developed Test (LDT)
The Hereditary Hemolytic Anemia Cascade begins with initial standard tests to detect possible causes of hemolytic anemia. If the results of the initial tests are suggestive of an abnormal or unstable hemoglobin, RBC membrane instability, or an enzyme or protein deficiency; or if the CBC data is suggestive of a hemoglobinopathy, appropriate testing will be performed at an additional charge. Depending on findings, one or more reflex tests may be required in order to provide a clinical interpretation. Tests added may include electrophoresis, solubility testing, mutational analysis, and/or sequencing.
Quantitation of hemoglobin by HPLC or electrophoresis is most definitive in individuals one year and older. If quantitation of hemoglobin was performed before age one, repeat testing is recommended. Abnormal hemoglobin variants may require additional testing, which increases TAT up to 21 days.
84220; 88184; 82955; 83021. Reflex components billed separately. Additional CPT codes may apply, 85555; 81479; 83068; 81269; 81259; 81363; 81364; 81249; 81443; 85660; 83020
|Component Test Code*||Component Chart Name||LOINC|
|3000908||Hereditary Hemolytic Anemia Interp|