Optimize dose, detect variable pharmocokinetics, and monitor patient adherence.
Prior to testing patient should have had uninterrupted imatinib therapy for at least 29 days with no change in dose or treatment for at least 8 days. Blood draw should be performed immediately prior to the next scheduled dose.
Plasma, Pre-dose (Trough) Draw - At a Steady State Concentration, in K2EDTA (Lavender or Pink) or Lithium Heparin (Green)
Separate from cells within 48 hours of collection. Centrifuge the whole blood for a minimum of 10 minutes to separate the plasma from cells. Carefully draw off the plasma starting from the top of the plasma layer, avoiding the cell layer (contamination of plasma with blood cells may interfere with results). Transfer 1 mL plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood, gel separator tubes, light blue (citrate), or yellow top tubes.
Ambient: 7 days; Refrigerated: 30 days; Frozen: 30 days
The therapeutic range is based on plasma pre-dose (trough) draw at steady-state concentration. Concentrations above 1000 ng/mL in chronic myelogenous leukemia (CML) patients, and above 1100 ng/mL in gastrointestinal stromal tumor (GIST) patients are statistically associated with an improved response.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
- Imatinib Mesylate