3000460
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Smith and Smith/RNP (ENA) Antibodies, IgG

SMITH_RNP
Example Reports
Negative
Positive

Ordering Recommendation

Useful for confirming a diagnosis of systemic lupus erythematosus (SLE) or mixed connective tissue disease (MCTD) following a positive ANA result. Antibodies may be useful in the differential diagnosis of other systemic autoimmune rheumatic diseases such as systemic sclerosis, Sjögren syndrome, polymyositis, dermatomyositis, and overlap syndromes.

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  Smith/RNP (ENA) Ab, IgG 19 Units or less
  Smith (ENA) Antibody, IgG 40 AU/mL or less

Interpretive Data




Components Interpretation
Smith/RNP (ENA) Antibody, IgG 19 Units or less: Negative
20-39 Units: Weak Positive
40-80 Units: Moderate Positive
81 Units or greater: Strong Positive
Smith (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
02/22/2022
X
N/A

CPT Codes

86235 x2

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Components

Component Test Code* Component Chart Name LOINC
0050085 Smith (ENA) Antibody, IgG 18323-6
0050470 Smith/RNP (ENA) Ab, IgG 33983-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-Sm
  • Anti-Smith (ENA) Antibody
  • Sm antibody IgG
  • Sm/RNP
  • Sm/RNP Antibody
Smith and Smith/RNP (ENA) Antibodies, IgG