Ordering Recommendation

Use to detect and document maternal use of ethanol during approximately the last trimester of a full-term pregnancy.

Mnemonic
ETG QQQ CD
Methodology

Qualitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Thu, Sat

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Umbilical Cord (At least 8 inches, approximately the width of a sheet of paper.)   Caution must be used when collecting specimen, to ensure no ethanol-containing personal care products (i.e., hand sanitizers, wipes, mouthwash) are used directly on the specimen or nearby during collection.

Specimen Preparation

Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or water. Pat the cord dry and transport at least 8 inches of umbilical cord in a routine urine collection cup or Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at (800) 522-2787. (Min: 6 inches)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.

Remarks
Stability

Ambient: 1 week; Refrigerated: 3 weeks; Frozen: 1 year

Reference Interval
Drugs/Drug Classes Cutoff Concentrations (ng/g)
Ethyl Glucuronide 5

Interpretive Data

Methodology: Qualitative Liquid Chromatography-Tandem Mass Spectrometry

This test is designed to detect and document exposure that occurred during approximately the last trimester of a full term pregnancy, to ethyl glucuronide, a common ethanol (alcohol) metabolite. Alternative testing is available to detect other drug exposures. The pattern and frequency of alcohol used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used alcohol during pregnancy. Detection of alcohol in umbilical cord tissue depends on extent of maternal use, as well as stability, unique characteristics of alcohol deposition in umbilical cord tissue, and the performance of the analytical method. Detection of alcohol in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.

Caution must be used when collecting specimen, to ensure no ethanol-containing personal care products (i.e., hand sanitizers, wipes, mouthwash) are used directly on the specimen or nearby during collection.

Compliance Category

Laboratory Developed Test (LDT)

Note

Absolute Minimum: 6 inches. EtG may be formed in vitro in umbilical cord segment exposed to ethanol vapors at room temperature.

Hotline History
N/A
CPT Codes

80321 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
3000444 Ethyl Gluc, Cord, Qual
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Ethyl Glucuronide, Umbilical Cord Tissue, Qualitative