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The patient information provided with the Integrated, Specimen #1 will be used to calculate the risk
Ordering Recommendation

Second-trimester screening test for trisomy 21 (Down syndrome), trisomy18, and open neural tube defects. Requires a previously submitted first-trimester specimen, Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT (3000147). Risks are determined after second-trimester specimen is received, using a combination of first- and second-trimester serum markers with or without first-trimester nuchal translucency measurement. 

Mnemonic
MS INT2
Methodology

Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

2-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation.

Collect

Serum Separator Tube (SST) or Plain Red.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Hemolyzed specimens.

Remarks

Requires that a previous first trimester specimen, Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT (ARUP test code 3000147), has been performed.

Stability

After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 year (Avoid repeated freeze/thaw cycles.)

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

This test is used to screen for fetal risk of Down syndrome (trisomy 21), trisomy 18, and Open Neural Tube Defect (ONTD, spina bifida).

Hotline History
N/A
CPT Codes

81511

Components
Component Test Code* Component Chart Name LOINC
0080021 Patient's AFP 1834-1
0080241 Estimated Due Date 11778-8
0080267 MoM for DIA 35738-4
0080268 Patient's DIA 23883-2
0080918 MoM for AFP 20450-3
0080920 Maternal Screen Interpretation 49586-1
0080922 Specimen 19151-0
0080923 Dating 21299-3
0080924 Insulin Req Maternal Diabetes 44877-9
0080925 Family Hx Neural Tube Defect 8670-2
0080926 Maternal Race 21484-1
0080927 Number of Fetuses 11878-6
0080932 Maternal Age At Delivery 21612-7
0080941 Patient's uE3 2250-9
0080943 MoM for uE3 20466-9
0081065 Nuchal Translucency (NT) 12146-7
0081068 MoM for PAPP-A 32123-2
0081069 Sonographer Certification # 49089-6
0081070 Sonographer Name 49088-8
0081071 Ultrasound Date 34970-4
0081074 MoM for NT 49035-9
0081158 Family History of Aneuploidy 32435-0
3000163 PAPP-A Maternal 48407-1
3000165 Smoking 64234-8
3000166 Crown Rump Length 11957-8
3000168 Nuchal Translucency (NT), Twin B
3000169 MoM for NT, Twin B 49035-9
3000170 Crown Rump Length, Twin B 11957-8
3000176 EER Maternal Serum, Integrated, Spcm2 11526-1
3000261 Patient's hCG, 2nd Trimester 19080-1
3000262 hCG MoM, 2nd Trimester 20465-1
3000264 Maternal Weight 29463-7
3000390 Gestational Age for Second Specimen 18185-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Second trimester screen
Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A