First-trimester screening test for trisomy 21 (Down syndrome) and trisomy 18. Does not include alpha fetoprotein for open neural tube defects. Requires nuchal translucency measurement performed by an ultrasonographer certified by the Fetal Medicine Foundation (FMF) or Nuchal Translucency Quality Review (NTQR).
Quantitative Chemiluminescent Immunoassay
Specimen must be drawn between 11 weeks, 0 days and 13 weeks, 6 days gestation. (Crown-Rump length (CRL) must be between 43-83.9 mm at time of specimen collection.)
Serum Separator Tube (SST) or Plain Red.
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
Plasma. Hemolyzed specimens.
Submit with Order: Patient's date of birth, current weight, number of fetuses present, patient's race, if the patient has had a previous pregnancy with a trisomy, if the patient is currently smoking, if this is a repeat sample, and the age of the egg donor if in vitro fertilization.
In addition to the above: the date of ultrasound, the CRL measurement, the nuchal translucency (NT) measurement and the name and certification number of the sonographer is required.
NT must be measured when the CRL is between 38-83.9 mm.
The NT measurement must also be performed by an ultrasonographer that is certified by one of the following agencies: Fetal Medicine Foundation (FMF) or Nuchal Translucency Quality Review (NTQR). To avoid possible test delays for an ultrasonographer that is new to our database, please contact the genetic counselor at (800) 242-2787 extension 2141 prior to sending specimen.
If an NT is unobtainable, order Maternal Serum Screening, Integrated (ARUP test codes 3000147 (collect in first trimester) and 3000149 (collect in second trimester)), which can be interpreted without an NT value.
After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 year (Avoid repeated freeze/thaw cycles.)
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
This test does not screen for Open Neural Tube Defect (ONTD). This test is used to screen for fetal risk of Down syndrome (trisomy 21) and trisomy 18.
|Component Test Code*||Component Chart Name||LOINC|
|0080920||Maternal Screen Interpretation||49586-1|
|0080927||Number of Fetuses||11878-6|
|0080932||Maternal Age At Delivery||21612-7|
|0081065||Nuchal Translucency (NT)||12146-7|
|0081068||MoM for PAPP-A||32123-2|
|0081069||Sonographer Certification #||49089-6|
|0081074||MoM for NT||49035-9|
|0081158||Family History of Aneuploidy||32435-0|
|3000166||Crown Rump Length||11957-8|
|3000168||Nuchal Translucency (NT), Twin B|
|3000169||MoM for NT, Twin B||49035-9|
|3000170||Crown Rump Length, Twin B||11957-8|
|3000172||EER Maternal Serum, First Trimester||11526-1|
|3000259||Patient's hCG, 1st Trimester||19080-1|
|3000260||hCG MoM, 1st Trimester||20465-1|
|3000263||Gestational Age Calculated at Collection||18185-9|
- Combined Screen
- First Trimester Screen