Maternal Serum Screen, Alpha Fetoprotein, hCG, Estriol, and Inhibin A (Quad)
Ordering Recommendation
Second-trimester screening test for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects.
New York DOH Approval Status
Specimen Required
Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation.
Serum Separator Tube (SST) or Plain Red.
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
Refrigerated.
Plasma. Hemolyzed specimens.
Submit with Order: Patient's date of birth, current weight, due date, dating method (US, LMP), number of fetuses present, patient's race, if the patient was diabetic at the time of conception, if there is a known family history of neural tube defects, if the patient has had a previous pregnancy with a trisomy, if the patient is currently smoking, if the patient is taking valproic acid or carbamazepine (Tegretol), if this is a repeat sample, and the age of the egg donor if in vitro fertilization.
After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 year (Avoid repeated freeze/thaw cycles.)
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
2-3 days
Reference Interval
By report
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
This test is used to screen for fetal risk of Down syndrome (trisomy 21), trisomy 18, and Open Neural Tube Defect (ONTD, spina bifida).
Hotline History
CPT Codes
81511
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0080021 | Patient's AFP | 1834-1 |
0080241 | Estimated Due Date | 11778-8 |
0080267 | MoM for DIA | 35738-4 |
0080268 | Patient's DIA | 23883-2 |
0080918 | MoM for AFP | 20450-3 |
0080920 | Maternal Screen Interpretation | 49586-1 |
0080922 | Specimen | 19151-0 |
0080923 | Dating | 21299-3 |
0080924 | Insulin Req Maternal Diabetes | 44877-9 |
0080925 | Family Hx Neural Tube Defect | 8670-2 |
0080926 | Maternal Race | 21484-1 |
0080927 | Number of Fetuses | 11878-6 |
0080932 | Maternal Age At Delivery | 21612-7 |
0080941 | Patient's uE3 | 2250-9 |
0080943 | MoM for uE3 | 20466-9 |
0081158 | Family History of Aneuploidy | 32435-0 |
3000165 | Smoking | 64234-8 |
3000171 | EER Maternal Serum, Quad | 11526-1 |
3000261 | Patient's hCG, 2nd Trimester | 19080-1 |
3000262 | hCG MoM, 2nd Trimester | 20465-1 |
3000263 | Gestational Age Calculated at Collection | 18185-9 |
3000264 | Maternal Weight | 29463-7 |
Aliases
- AFP 4 Marker Screen
- AFP MS4 (Quad)
- Alpha Fetoprotein, hCG, Estriol, and Inhibin
- Maternal Screening, AFP 4 Marker
- QUAD
- Quad AFP
- Quad screening