Ordering Recommendation

Use to detect and quantitate NPM1 mutant transcripts (type A, B, and D). Use to monitor for minimal residual disease and assess the risk of disease relapse. 




Quantitative Reverse Transcription Polymerase Chain Reaction




5-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Whole blood or bone marrow in lavender (EDTA).

Specimen Preparation

Whole Blood: Transport 5 mL whole blood. (Min: 3 mL)
Bone Marrow:
Transport 3 mL bone marrow. (Min: 1 mL)
Refrigerate immediately. Specimens must be received within 48 hours of collection due to lability of RNA.

Storage/Transport Temperature

Whole Blood or Bone Marrow: CRITICAL REFRIGERATED. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum, plasma, ambient or frozen bone marrow or whole blood, CSF, or FFPE tissue. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed or clotted specimens.
Ambient whole blood and ambient bone marrow specimens past 7 days will be canceled. Refrigerated whole blood or bone marrow past 7 days will be canceled.


Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
3000067 NPM1 Quantitative, Source 31208-2
3000068 NPM1 Quantitative, Result 54448-6
3000069 NPM1 Quantitative, Ratio
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


NPM1 Mutation Detection by RT-PCR, Quantitative