Ordering Recommendation

Not recommended. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.


Qualitative Immunodiffusion




2-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation


Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

None detected.

Interpretive Data

Coccidioides infection is demonstrated by the detection of IgM antibody to the Immunodiffusion Tube Precipitin (IDTP) antigen. IgM antibody may be detected 1 to 3 weeks after the onset of primary infection and may suggest active or recent infection. IgM antibody is rarely detected 6 months after infection but may reappear with relapse and may persist in disseminated cases.

IgG antibody may also be demonstrated in response to the Immunodiffusion Complement Fixation (IDCF) antigen and may represent active or past infection. Negative fungal serology does not rule out current infection.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.


This test uses culture filtrates of Coccidioides immitis and includes IDCF and IDTP antigens.

Hotline History
CPT Codes


Component Test Code* Component Chart Name LOINC
3000064 Coccidioides by Immunodiffusion, CSF 21209-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Coccidioides Antibody (TP Antigen)
  • Coccidioides Antibody (TP Antigen), Immunodiffusion
  • Coccidioides antibody, S
  • Coccidioides Precipitin
  • Coccidioidomycosis IgG/IgM
  • San Joaquin Fever Antibody
  • San Joaquin Valley fever
  • Valley Fever antibodies, Cocci ID
Coccidioides immitis by Immunodiffusion, CSF