2014694
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Maternal T Cell Engraftment in SCID, Pre-Engraftment Specimen

SCID-PRE
Example Reports
Example

Ordering Recommendation

Monitor engraftment of maternal T cells in patients with severe combined immunodeficiency (SCID) prior to allogenic stem cell transplantation.

New York DOH Approval Status

This test is not New York state approved. There are no New York state-approved laboratories available. Submit a Non-Permitted Laboratory Request Form (NPL) to the NYDOH prior to collection of specimen. If NPL is approved by NYDOH, and sample is received at ARUP, testing will be performed.

Specimen Required

Patient Preparation
Collect

To collect buccal brush, use a sterile nylon bristle cytology brush. DO NOT USE COTTON SWABS! Use 2 brushes per patient. Rinse mouth thoroughly. Gently brush the right and left inside surface of the cheek and between the gums and lips for 15 seconds while moving the brush up and down and at the same time rotating the brush. Place brushes into a sterile tube or equivalent container to ship. Cut the end of the brush into the container if needed to fit.

Available online through eSupply using ARUP Connect (Chimerism Recipient Pretransplant Collection Brush Kit (ARUP Supply 64627)). Or contact ARUP Client Services at 800-522-2787.

Specimen Preparation

Collect 3-4 brush samples from patient and place in dry, sterile container for transport.

Storage/Transport Temperature

Preferred transport temp: Room temperature. Also acceptable: Refrigerated

Unacceptable Conditions
Remarks
Stability

Room Temperature: 1 week; Refrigerated: 1 month; Frozen: unacceptable

Methodology

Polymerase Chain Reaction (PCR) / Fragment Analysis

Performed

Sun-Sat

Reported

5-9 days

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

To complete Maternal T Cell Engraftment in SCID testing, samples should be collected to perform the following three tests: (1) a buccal brush collected from the patient for Maternal T Cell Engraftment in SCID, Pre-Engraftment Specimen (ARUP test code 2014694), used as a genetic baseline for the patient; (2) a peripheral blood sample from the biological mother for Maternal T Cell Engraftment in SCID, Maternal Specimen (ARUP test code 2014704), used as a genetic baseline for the mother; (3) a peripheral blood sample collected from the patient for Maternal T Cell Engraftment in SCID (ARUP test code 2014699). T cells isolated from the blood sample will be genotyped for comparison to the patient and the biological mother's baseline genotypes.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/03/2025
X
N/A

CPT Codes

81265

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Components

Component Test Code* Component Chart Name LOINC
2014695 Specimen, Maternal Engraftment Pre
2014696 Maternal Engraftment, Pre Interp
2014697 Mat Engraftment, Pre, Informative Loci
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Maternal cell engraftment
  • Maternal engraftment
  • SCID
  • SCID engraftment
Maternal T Cell Engraftment in SCID, Pre-Engraftment Specimen